Objective To analysis the application value and Th1/Th2 immune drift of Benefit stomach blood method in the treatment of precancerous lesions of gastric cancer, clearing the positive clinical significance of TCM on precancerous lesions of gastric cancer.
Methods One hundred precancerous lesions of gastric cancer patients were randomly divided into two groups, 50 cases in each group. Giving rabeprazole sodium enteric-coated tablets and capsule of teprenone for control group, while above medicine and combined benefit stomach blood decoction for observe group. Then the clinical curative effect, stomachoscopy and Th1/Th2 immune index changes of the two groups were analysed.
Results After 12-week treatment, the score of stomach pain/bloting/anorexia were obviously lower in treatment group (1.52±1.03), (1.33±1.05), (1.38±1.01) than those in control group (2.01±1.16), (2.32±1.18), (2.28±1.17), all
P<0.05. The score of inflammation pathological/gland atrophy/IM/Dys were obviously lower in treatment group (1.39±1.01), (1.37±1.03), (1.39±1.06), (1.27±1.06) than those in control group (2.33±1.17), (2.51±1.18), (2.09±1.05), (2.03±1.26), all
P<0.05. The value of IL-2 and INF-γ were obviously higher in treatment group[(9.52±1.46)pg/ml, (20.37±5.20)pg/ml] than those in control group[(5.92±1.46)pg/ml, (14.89±4.92)pg/ml], all
P<0.05. The value of IL-4 and IL-6 were obviously lower in treatment group[(4.85±1.93)pg/ml, (50.43±13.51)pg/ml] than those in control group[(8.74±1.84)pg/ml, (80.16±11.36)pg/ml],
P<0.05.
Conclusion Benefit stomach soup of blood can not only effectively regulate the precancerous lesions of gastric cancer patients' Th1/Th2 balance, at the same time also can effectively improve the clinical therapeutic effect.
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