The role of human placental growth factor and human heme oxygenase-1 in the pathogenesis of preeclampsia

Objective To investigate the role of human placental growth factor and human heme oxygenase-1 in the pathogenesis of preeclampsia. Methods Ninety cases of mild preeclampsia pregnant women were selected as mild preeclampsia group 90 cases of severe preeclampsia pregnant women were selected as severe preeclampsia group and 90 healthy pregnant women were selected as control group from January, 2014 to January, 2017 in Lishui City People's Hospital obstetric. The serum levels of placental growth factor and heme oxygenase-1 were determined by enzyme-linked immunosorbent assay (ELISA). Results The levels of 24 h urinary protein mean arterial pressure serum placental growth factor and heme oxygenase-1 among the three groups were statistically significant (P<0.05). The 24 h urinary protein and mean arterial pressure in mild preeclampsia group and severe preeclampsia group were significantly higher than that in control group (P<0.05). The 24 h urinary protein and mean arterial pressure in severe preeclampsia group were significantly higher than that in mild preeclampsia group (P<0.05). The levels of serum placental growth factor and heme oxygenase-1 in mild preeclampsia group and severe preeclampsia group were lower than those in control group (P<0.05). The levels of serum placental growth factor and heme oxygenase-1 in severe preeclampsia group were lower than those in mild preeclampsia group (P<0.05). The level of serum placental growth factor and heme oxygenase-1 in pregnant women with preeclampsia were negatively correlated with 24 h urinary protein and mean arterial pressure (P<0.05). There was positive correlation between serum placental growth factor and serum heme oxygenase-1 in pregnant women with preeclampsia (P<0.05). Conclusion Preeclampsia maternal serum placental growth factor and serum heme oxygenase-1 levels decrease.The serum placental growth factor and serum heme oxygenase-1 level are related to the severity of preeclampsia both may interact during the onset of preeclampsiainvolved together the development of preeclampsia.