Prognostic role of inflammatory biomarkers in gliomas

Objective To assess the prognostic significance of inflammatory biomarkers, including the C-reactive protein (CRP), neutrophil lymphocyte ratio (NLR) and the erythrocyte sedimentation rate (ESR), in gliomas. Methods Clinico-pathological data of 178 patients with gliomas in Zhejiang Rui'an Renmin Hospital between January 2010 and January 2016 was analyzed retrospectively in this study. Survival curves were described by Kaplan-Meier method and compared by Log-rank test. The univariate and multivariate analyses were performed with the Cox proportional hazard model to identify the prognostic factors. Results The NLR and CRP were associated with the tumor size, differentiation degree and lymphovascular invasion (all P<0.05). PLR was positively correlated with the tumor size (P<0.05). The Kaplan-Meier curves showed that the patients with gliomas had a longer time in the low NLR group, low CRP group and low ESR group than in the high NLR group, high CRP group and high ESR group respectively, showing a significant difference (all P<0.05). The multivariate analyses showed that the differentiation degree, CRP and NLR were independent factors for predicting overall survival of gliomas patients. Conclusion The CRP and NLR have prognostic value for predicting overall survival in gliomas patients.