Correlation between TCM constitution and Hysteromyoma：a meta-analysis

Objective To explore the difference between the distribution of traditional Chinese medicine (TCM) constitution of hysteromyoma and non-hysteromyoma population through the meta-analysis of the clinical studies on the correlation between hysteromyoma and TCM constitution, in order to provide higher level evidence based on larger sample for clinical and scientific research. Methods Literatures of CBMdisc, CNKI, Wanfang database, VIP, PubMed and Embase database from the database creation to May 31,2017 were searched, and Meta-analysis was performed by Review Manager 5.2 software. Results Totally 6 studies from 2012-2015 were included with 2 193 individuals. The results showed that balanced constitution (OR=0.13, 95% CI 0.04-0.36)was a protective factor of hysteromyoma (P<0.05) while phlegm-dampness (OR=1.67, 95% CI 1.23-2.28), qi stagnation(OR=1.97, 95% CI 1.48-2.64)and blood stasis constitutions(OR=4.56, 95%CI 2.54-8.19)were risk factors of hysteromyoma (all P<0.05), and there were no obvious correlations among qi deficiency, yang deficiency, yin deficiency, damp-heat constitutions and hysteromyoma (all P>0.05). Conclusion This study provides evidence for the prevention and treatment of hysteromyoma in TCM. However, most of the included studies are moderate quality, more high-quality, multi-center, large-sample studies are expected to provide higher level evidence.