Objective Observe the clinical efficacy of
Heshi Yulin Recipe combined with traditional Chinese medicine fumigation treatment for recurrent implantation failure(RIF) of kidney deficiency and blood stasis type, and to explore its influence on patients ' clinical pregnancy rate, embryo implantation rate, hormone level and uterine artery flow.
Methods A total of 62 patients who were diagnosed as RIF of kidney deficiency and blood stasis type in Ningbo Women and Children's Hospital from February 2017 to September 2018 were divided into control group and observation group by random number table method with 31 cases each group. There was no statistically difference significant in basic information between two groups(
P>0.05). The patients in the control group were given only oral treatment with aspirin enteric-coated tablets for 3 times a day, 1 tablet each time and 25 mg per tablet. The patients in the observation group were given treatment combining water decoction of
Heshi Yulin Recipe for one potion per day, two times on each morning and evening, 200 mL per time, and once every other day with traditional Chinese medicine fumigation. All patients were treated continuously for 3 menstrual cycles. The clinical effects after treatment of the two groups were compared. The clinical pregnancy rate, embryo implantation rate, monitored the blood hormone levels, endometrial thickness and type, and uterine artery blood flow in mid-secretory phase were calculated.
Results The clinical pregnancy rate of the observation group was 51.61%, which was obviously higher than that of the control group(25.81%),
P<0.05. The embryo implantation rate of the observation group was 31.67%, which was obviously higher than that of the control group(15.25%),
P<0.05. The blood estradiol E2, P level and uterine B-ultrasound of the observation group were significantly better than those in the control group(all
P<0.05).
Conclusion Heshi Yulin Recipe combined with traditional Chinese medicine fumigation has exact curative effect, it is beneficial to improve the clinical pregnancy rate and embryo implantation rate of patients who are diagnosed as RIF of kidney deficiency and blood stasis type. The synergistic use of
Heshi Yulin Recipe and fumigation can improve the endometrial receptivity, lower the uterine artery blood flow resistance, regulate hormone level and improve endocrine.
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