Clinical efficacy of oral and external use of traditional Chinese medicine combined with fasudil in treatment of lower extremity arteriosclerosis obliterans in elderly patients

Objective To investigate the Clinical efficacy of oral and external use of traditional Chinese medicine combined with fasudil in the treatment of lower extremity arteriosclerosis obliterans in elderly patients and its effect on ABI, serum CRP and Hcy. Methods One hundred and four elderly patients with lower extremity arteriosclerosis obliterans admitted to Wenzhou Hospital of Traditional Chinese Medicine from August 2016 to August 2018 were studied. They were randomly divided into control group and observation group, 52 cases in each group. The control group was treated with fasudil. The observation group was combined with traditional Chinese medicine Simiao Yongan Decoction on the basis of the control group.The two groups were treated for one month. The levels of ABI, CRP and Hcy before and after treatment were compared and analyzed. The indexes of dorsal pedal artery(vessel diameter, peak velocity and blood flow) were measured. The clinical efficacy and adverse reactions were observed. Results The total effective rate of the observation group was higher than that of the control group(94.23% vs. 76.92%, χ²=6.310, P=0.012). After treatment, the vessel diameter and blood flow of the two groups significantly increased, and the peak flow rate significantly decreased(P<0.05). Compared with the control group, the observation group had a higher level of blood vessel diameter and blood flow and a lower peak flow velocity(P<0.05).The levels of ABI, CRP and Hcy after treatment in the two groups were significantly improved compared with before treatment, and the ABI levels in the observation group were higher than those in the control group, while the levels of CRP and Hcy were lower than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(11.54% vs. 13.46%, χ²=0.088, P=0.767). Conclusion The combination of oral and external use of traditional Chinese medicine and fasudil has definite curative effect on elderly ASO. It can effectively inhibit inflammation, improve blood flow of lower limbs, increase ankle-brachial index and reduce the level of Hcy. There is no obvious adverse drug reactions. It is an effective treatment program.