Volume 19 Issue 1
Jan.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(1): 62-64,68
QIU Feng, SONG Chun-yan, QIN Fu-chuang, TIAN Si-qi, HUANG Rong, MA Xi-lie, ZENG Jian-ping. Analysis of the value of serum irisin in the diagnosis of obstructive sleep apnea syndrome[J]. Chinese Journal of General Practice, 2021, 19(1): 62-64,68. doi: 10.16766/j.cnki.issn.1674-4152.001731
Citation: QIU Feng, SONG Chun-yan, QIN Fu-chuang, TIAN Si-qi, HUANG Rong, MA Xi-lie, ZENG Jian-ping. Analysis of the value of serum irisin in the diagnosis of obstructive sleep apnea syndrome[J]. Chinese Journal of General Practice, 2021, 19(1): 62-64,68. doi: 10.16766/j.cnki.issn.1674-4152.001731
shu

Analysis of the value of serum irisin in the diagnosis of obstructive sleep apnea syndrome

doi: 10.16766/j.cnki.issn.1674-4152.001731
  • 1.

    Department of Emergency Medicine, Shulan (Hangzhou) Hospital, Hangzhou, Zhejiang 310006, China

Funds:

 LGF19H090007

  • Received Date: 2020-04-16
    Available Online: 2022-02-19
    Abstract
  •   Objective  To investigate the correlation between the degree of obstructive sleep apnea syndrome (OSAS) and the level of irisin in serum.  Methods  Ninety-six OSAS patients diagnosed in Shulan (Hangzhou) Hospital from May 2017 to December 2018 were selected in the OSAS group, and according to the apnea hypopnea index, they were divided into mild (30 cases), moderate (30 cases) and severe (36 cases), another 30 healthy people were selected as the control group. The indexes of apnea hypopnea, the lowest oxygen saturation and the longest time of apnea were measured by polysomnography. The level of serum irisin was measured by enzyme-linked immunosorbent assay.  Results  The serum irisin level [(1.43±0.28) ng/mL], the lowest oxygen saturation [(70.47±3.81)%] in the OSAS group were significantly lower than those in the control group [(2.82±0.54) ng/mL and (94.58±3.21)%], the apnea hypopnea index [(27.64±3.29) times/h], the longest apnea time [(37.45±4.23) s] were significantly higher than those in the control group [(2.37±1.08) times/h and (1.73±0.65) s], the difference was statistically significant (all P < 0.05). With the increase of the severity of the disease, the level of serum irisin, the lowest oxygen saturation and the longest apnea time decreased. In the OSAS group, the index of apnea hypopnea and the longest time of apnea were negatively correlated with the level of serum irisin (r=-0.717, -0.765; all P < 0.05), and the lowest oxygen saturation was positively correlated with the level of serum irisin (r=0.747, P < 0.05). According to the gold standard of polysomnography, the sensitivity and specificity of irisin in the diagnosis of OSAS were 68.8% and 93.3%, respectively.  Conclusion  The serum irisin level of OSAS patients is related to the severity of OSAS. The more severe OSAS, the lower the serum irisin level.

     

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