Volume 19 Issue 4
Apr.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(4): 530-533
LI Shi-wei, YU Wei-hua, CHEN De-yu, YAN Ting, ZHENG Jun-jun, FENG Huan. Risk assessment of carotid intimal thickening in elderly patients with type 2 diabetes by coronary risk index: Inverted U curve[J]. Chinese Journal of General Practice, 2021, 19(4): 530-533. doi: 10.16766/j.cnki.issn.1674-4152.001853
Citation: LI Shi-wei, YU Wei-hua, CHEN De-yu, YAN Ting, ZHENG Jun-jun, FENG Huan. Risk assessment of carotid intimal thickening in elderly patients with type 2 diabetes by coronary risk index: Inverted U curve[J]. Chinese Journal of General Practice, 2021, 19(4): 530-533. doi: 10.16766/j.cnki.issn.1674-4152.001853
shu

Risk assessment of carotid intimal thickening in elderly patients with type 2 diabetes by coronary risk index: Inverted U curve

doi: 10.16766/j.cnki.issn.1674-4152.001853
  • 1.

    Department of Nursing, the Third Affiliated Hospital of Anhui Medical University ( Hefei First People's Hospital) ，Hefei，Anhui 230061 ,China

Funds:

 81771567

  • Received Date: 2020-09-04
    Available Online: 2022-02-16
    Abstract
  •   Objective  To explore the predictive value of coronary risk index (CRI) for carotid atherosclerosis (CAD) in elderly patients with type 2 diabetes mellitus (T2DM) and provide references for clinical screening of risk for CAD.  Methods  A total of 156 elderly patients with T2DM who were treated in two third-class hospitals in Hefei from September 2019 to December 2019 were selected. On the basis of carotid artery intimal thickening and plaque formation, the patients were divided into non-carotid arteriosclerosis groups: Control group (55 cases), carotid artery intimal thickening group (52 cases) and carotid artery plaque formation group (49 cases). The clinical data of each group were recorded. Data were analysed using SPSS 25.0.  Results  Spearman correlation analysis revealed that the coronary heart disease risk index was positively correlated with carotid artery intima thickness in the elderly patients with T2DM (r=0.158, P=0.049). With the quartile of CRI as the critical value, the coronary heart disease risk index was divided into four intervals (Q1-Q4), and carotid artery intima thickness was analysed via logistic regression analysis. In the Q1-Q3 interval, as the risk of carotid artery intimal thickening increased as CRI increased (OR values for Q1, Q2 and Q3 were 1.000, 1.677 and 5.333, respectively). In the Q4 interval, increased CRI the risk of carotid artery intimal thickening slightly decreased as CRI increased (OR=2.970). The increase in ratio displayed an inverted U-shaped relationship with the risk of carotid artery intimal thickening in the elderly patients with T2DM.  Conclusion  When CRI ranges from 3.59 to 4.14, medical staff should carefully observe if patients are showing clinical signs of microvascular diseases; if the CRI is at an excessively high level for a long time (CRI ≥4.15), the staff should be alerted to the occurrence of occult microvascular diseases. Clinically, the Total Cholesterol/High-Density Lipoprotein Cholesterol (TC/HDL-C) ratio can be included in screening for CAD among elderly patients with T2DM to comprehensively evaluate the risk of CAD in these patients.

     

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