Volume 19 Issue 4
Apr.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(4): 554-557,576
Ll Ying, YANG Bo, ZHANG Jing. The prognostic value of SII, NLR, PLR and LMR in the stage of ⅠA-ⅡA2 cervical cancer[J]. Chinese Journal of General Practice, 2021, 19(4): 554-557,576. doi: 10.16766/j.cnki.issn.1674-4152.001859
Citation: Ll Ying, YANG Bo, ZHANG Jing. The prognostic value of SII, NLR, PLR and LMR in the stage of ⅠA-ⅡA2 cervical cancer[J]. Chinese Journal of General Practice, 2021, 19(4): 554-557,576. doi: 10.16766/j.cnki.issn.1674-4152.001859
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The prognostic value of SII, NLR, PLR and LMR in the stage of ⅠA-ⅡA2 cervical cancer

doi: 10.16766/j.cnki.issn.1674-4152.001859

  • Department of Oncology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0384

  • Received Date: 2020-12-10
    Available Online: 2022-02-16
    Abstract
  •   Objective  To investigate the prognostic value of systemic immune inflammatory index (SⅡ), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR) in patients with cervical cancer of stage ⅠA-ⅡA2 before treatment.  Methods  196 patients with cervical cancer of stage ⅠA2-ⅡA2 who were initially diagnosed in the First Affiliated Hospital of Bengbu Medical College from May 2012 to December 2014 were included. The Cut off values of NLR, PLR, LMR and SⅡ were calculated and divided into high and low value groups.The relationship between the four indexes and clinicopathological parameters in the high and low value groups were observed. The difference in overall survival between high and low value groups were compared. Univariate and multivariate analyses were performed to assess the predictive validity of independent risk factors, and establish a nomogram.  Results  NLR was correlated with histological type and lymphatic vascular stromal infiltration, PLR was correlated with histological type and tumor size, and SⅡ was correlated with histological type, with statistically significant difference respectively (all P < 0.05). The high value group of NLR, PLR and SⅡ and the low value group of LMR had shorter OS, and the difference was statistically significant (all P < 0.05). PLR, SⅡ, histological type and lymph node metastasis were independent risk factors for OS (all P < 0.05). Predictive validity: PLR>SⅡ>lymph node metastasis>the histological type (AUC: 73.2%>71.9%>65.1%>37.0%). The accuracy of the nomogram was high (OS3/OS5 AUC: 90.7%/79.1%).  Conclusion  The value of PLR and SⅡ before treatment can be reliable indicators to predict the prognosis of patients with stage ⅠA2~ⅡA2 cervical cancer.

     

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