Volume 19 Issue 5
May  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(5): 782-785
CHEN Hai-rui, ZHANG Jian-ping, WANG Xiao-gao, WANG Ying, YU Chao-wen, LU Ran, CHEN Shi-yuan, SUN Yong, GUAN Ze-yu. Comparative study of different drug delivery methods in the catheter-directed thrombectomy for deep venous thrombosis in lower extremities[J]. Chinese Journal of General Practice, 2021, 19(5): 782-785. doi: 10.16766/j.cnki.issn.1674-4152.001916
Citation: CHEN Hai-rui, ZHANG Jian-ping, WANG Xiao-gao, WANG Ying, YU Chao-wen, LU Ran, CHEN Shi-yuan, SUN Yong, GUAN Ze-yu. Comparative study of different drug delivery methods in the catheter-directed thrombectomy for deep venous thrombosis in lower extremities[J]. Chinese Journal of General Practice, 2021, 19(5): 782-785. doi: 10.16766/j.cnki.issn.1674-4152.001916
shu

Comparative study of different drug delivery methods in the catheter-directed thrombectomy for deep venous thrombosis in lower extremities

doi: 10.16766/j.cnki.issn.1674-4152.001916
  • 1.

    Department of Vascular Surgery of Taihe County People's Hospital, Fuyang, Anhui 236000, China

Funds:

 KJ2019A0327

 20200343

 BYKY1862ZD

 BYKF1886

 2020fyjyxm14

  • Received Date: 2020-08-09
    Available Online: 2022-02-16
    Abstract
  •   Objective  To explore the therapeutic effects of different drug delivery methods for catheter-directed thrombectomy (CDT) of deep venous thrombosis (DVT).  Methods  Forty-six patients with DVT admitted to the Department of Ventilators of Taihe County People's Hospital from January 2017 to January 2020 were selected and divided into 24-hour continuous administration group (23 cases) and intermittent administration group (23 cases) according to the method of urokinase administration during CDT treatment. Plasma D-dimer content and fibrinogen value were monitored, and the total dosage of urokinase was counted. The efficacy was observed through the degree of lower limb swelling regression and deep venous angiography.  Results  The increase of plasma D-dimer value was more obvious in the continuous administration group than in the intermittent administration group, and the difference on the second day after thrombolysis were (81.87±12.32) mg/L and (63.53±15.75) mg/L, respectively, with statistically significant difference (P < 0.001). The amount of total urokinase in the continuous administration group was lower [(328±65) million units] than that in the intermittent administration group [(445±21) million units], with statistical significance (P < 0.001). The lower extremity swelling subsided better in the continuous administration group, and the difference of calf circumference before and after thrombolytic therapy were (1.27±0.54) cm and (2.13±0.78) cm in the intermittent administration group (P < 0.001), respectively. Angiography images confirmed that thrombolysis in the vascular lumen was more in the continuous administration group. The venous patency score (4.74±1.55) was statistically significant compared with that of the intermittent administration group (6.68±1.32, P < 0.001).  Conclusion  Compared with intermittent administration of D-dimer, CDT method in the treatment of DVT with continuous administration of urokinase has more value. The amount of urokinase is less, patients have better lower leg swelling subsidence and the clinical effect is better.

     

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