Volume 19 Issue 7
Jul.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(7): 1091-1094, 1102
LUO Wen-ping, LI Xiao-yu, LUO Song, LIU Xiao-lin. Relationship between serum lipoprotein (a) level and CISS classification and severity of ischemic stroke in youth[J]. Chinese Journal of General Practice, 2021, 19(7): 1091-1094, 1102. doi: 10.16766/j.cnki.issn.1674-4152.001992
Citation: LUO Wen-ping, LI Xiao-yu, LUO Song, LIU Xiao-lin. Relationship between serum lipoprotein (a) level and CISS classification and severity of ischemic stroke in youth[J]. Chinese Journal of General Practice, 2021, 19(7): 1091-1094, 1102. doi: 10.16766/j.cnki.issn.1674-4152.001992
shu

Relationship between serum lipoprotein (a) level and CISS classification and severity of ischemic stroke in youth

doi: 10.16766/j.cnki.issn.1674-4152.001992

  • Department of Neurology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0364

  • Received Date: 2020-11-25
    Available Online: 2022-02-16
    Abstract
  •   Objective  To explore the relationship between serum lipoprotein (a) [Lp(a)] and ischemic stroke in young people with different Chinese ischemic stroke subtypes (CISS classification), and provide evidence for its prevention and treatment.  Methods  The clinical data of 122 young patients with ischemic stroke treated in the First Affiliated Hospital of Bengbu Medical College from April 2017 to December 2019 were collected and included in the young stroke group, and 122 cases of ischemic stroke patients aged ≥ 45 years who were hospitalised during the same period were randomly admitted as the middle-aged and elderly stroke group. The traditional risk factors and serum Lp(a) levels between the two groups were compared. According to the CISS classification, pathogenesis and NIHSS scores at the time of admission, young patients with ischemic stroke were divided into different groups. The serum Lp(a) levels were compared between the groups. Multivariate logistic regression was used to analyse the independent influencing factors of ischemic stroke in young people.  Results  The serum Lp(a) level in the young stroke group was significantly higher than that in the middle-aged and elderly stroke group (t=7.317, P < 0.001). In different CISS classifications, serum Lp(a) levels in LAA, PAD, CS, OE, and UE groups were (381.38±62.46) mg/L, (297.94±43.97) mg/L, (283.00±39.33) mg/L, (279.25±38.22) mg/L, (292.92±34.93) mg/L, the difference between the groups was statistically significant (F=22.272, P < 0.001). The serum Lp(a) level of the LAA group was significantly higher than that of the PAD group, CS group, OE group and UE group(all P < 0.05), but there was no significant difference among the other four subtypes (all P > 0.05). Moreover, no significant difference was observed in the serum Lp(a) levels amongst patients with different pathogenesis of LAA (F=0.264, P=0.851), but a significant difference was noted in the serum Lp(a) levels amongst patients with different NIHSS scores (F=8.579, P < 0.001). Hyperlipidaemia, smoking and Lp(a)>300 mg/L were independent influencing factors of LAA subtypes in young patients with ischemic stroke.  Conclusion  Elevated serum Lp(a) level is one of the independent risk factors for ischemic stroke in young people. It plays an important role in patients with large atherosclerosis and can be used to assess the severity of the disease. Attention should be paid to monitoring and intervention.

     

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