Volume 19 Issue 7
Jul.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(7): 1107-1110, 1178
ZHU Xin-ying, ZHAO Li-wei, MENG Xia, YANG Liang, JIAO Li, MA Huan. Short-term efficacy of Xiangsha Pingwei Granule in the treatment of Helicobacter pylori gastritis with dyspepsia[J]. Chinese Journal of General Practice, 2021, 19(7): 1107-1110, 1178. doi: 10.16766/j.cnki.issn.1674-4152.001996
Citation: ZHU Xin-ying, ZHAO Li-wei, MENG Xia, YANG Liang, JIAO Li, MA Huan. Short-term efficacy of Xiangsha Pingwei Granule in the treatment of Helicobacter pylori gastritis with dyspepsia[J]. Chinese Journal of General Practice, 2021, 19(7): 1107-1110, 1178. doi: 10.16766/j.cnki.issn.1674-4152.001996
shu

Short-term efficacy of Xiangsha Pingwei Granule in the treatment of Helicobacter pylori gastritis with dyspepsia

doi: 10.16766/j.cnki.issn.1674-4152.001996

  • Department of Gastroenterology, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050050, China

Funds:

 20190638

  • Received Date: 2020-09-19
    Available Online: 2022-02-16
    Abstract
  •   Objective  To evaluate the efficacy and safety of Xiangsha Pingwei Granule in the treatment of Helicobacter pylori (H. pylori) gastritis with dyspepsia.  Methods  Total 240 H. pylori gastritis patients with dyspepsia were randomly divided into control group and observation group, 120 cases each. Control group received 220 mg Bismuth Potassium Citrate+Rabeprazole 10 mg+Amoxicillin 1 000 mg+Clarithromycin 500 mg, oral twice a day for 14 days; observation group received Xiangsha Pingwei Granule 10 g twice a day for 14 days based on the control group. H. pylori eradication rate, TCM clinical symptom score, serum pepsinogen (PG)Ⅰ, PGⅡ, pepsinogen ratio (PGR) levels and adverse reactions were compared between the two groups.  Results  There was no significant difference in the eradication rate of H. pylori between the two groups (90.4% vs. 93.8%, χ2=0.890, P=0.345). The total effective rate of observation group was 89.5%, which was significantly higher than 79.5% of the control group (χ2=4.325, P=0.038). The scores of TCM symptoms of the two groups decreased with time. The decrease of the above symptom scores in the observation group was significantly higher than control group. The overall level of the above symptom scores in the observation group was significantly lower than control group. The serum levels of PGⅠ, PGⅡ and PGR in the two groups decreased with time. The decrease of the above indexes in the observation group was significantly greater than control group. The overall level of the above indexes in the observation group was significantly lower than that in the control group. There were 20 cases (17.5%) of adverse reactions in observation group, which was significantly lower than 32 cases (28.6%) in the control group (χ2=3.878, P=0.049).  Conclusion  Xiangsha Pingwei Granule combined with quadruple therapy in the treatment of H. pylori gastritis complicated with dyspepsia has good clinical efficacy and safety, which is worthy of clinical promotion.

     

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