Volume 19 Issue 7
Jul.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(7): 1131-1134
CHEN Jin-qiang, LI Chun-da, LI Fu-qiang, LU Li-ming, FANG Bin, JIN Zhi-hua. Analysis and treatment of the risk factors for spontaneous peritonitis in patients with decompensated liver cirrhosis[J]. Chinese Journal of General Practice, 2021, 19(7): 1131-1134. doi: 10.16766/j.cnki.issn.1674-4152.002003
Citation: CHEN Jin-qiang, LI Chun-da, LI Fu-qiang, LU Li-ming, FANG Bin, JIN Zhi-hua. Analysis and treatment of the risk factors for spontaneous peritonitis in patients with decompensated liver cirrhosis[J]. Chinese Journal of General Practice, 2021, 19(7): 1131-1134. doi: 10.16766/j.cnki.issn.1674-4152.002003
shu

Analysis and treatment of the risk factors for spontaneous peritonitis in patients with decompensated liver cirrhosis

doi: 10.16766/j.cnki.issn.1674-4152.002003

  • Department of Infectious Diseases, Shaoxing Central Hospital, Shaoxing, Zhejiang 312030, China

Funds:

 2020KY990

  • Received Date: 2020-09-09
    Available Online: 2022-02-16
    Abstract
  •   Objective  To explore the risk factors and treatment of spontaneous peritonitis in patients with decompensated liver cirrhosis.  Methods  A total of 120 patients with decompensated liver cirrhosis who were treated in our hospital from January 2011 to December 2019 were divided into the concurrent group and non-complicated group based on whether they were complicated by spontaneous peritonitis (60 cases in each group). Logistic regression analysis was used to analyse the risk factors of spontaneous peritonitis in patients with decompensated liver cirrhosis. According to the different treatment drugs, the concurrent components were divided into the piperacillin and sulbactam group and ceftriaxone group (30 cases in each group). The clinical efficacy and inflammatory factor levels of the two groups were compared.  Results  Univariate analysis showed that the incidence of gastrointestinal bleeding, past history of SBP, Child-Pugh classification, total bilirubin level and blood sodium level had a certain effect on patients with decompensated liver cirrhosis complicated with spontaneous peritonitis (all P < 0.05). Multivariate analysis showed that gastrointestinal bleeding, Child-Pugh classification and total bilirubin levels were independent risk factors for spontaneous peritonitis in patients with decompensated liver cirrhosis (OR=0.191, 0.259, 0.922, all P < 0.05). The total effective rate of treatment in the piperacillin and sulbactam group was apparently higher than that in the ceftriaxone group (P < 0.05). After treatment, the levels of serum procalcitonin and C-reactive protein in the two groups were significantly lower than those before treatment (all P < 0.05), and the levels in the piperacillin and sulbactam group were apparently lower than those in the ceftriaxone group (all P < 0.05).  Conclusion  Gastrointestinal bleeding, high Child-Pugh grade and high total bilirubin levels are independent risk factors for spontaneous peritonitis in patients with decompensated liver cirrhosis. Piperacillin and sulbactam can be used in patients with spontaneous peritonitis to reduce the level of inflammatory factors in the body.

     

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