Volume 19 Issue 7
Jul.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(7): 1138-1141
LU Bao-xia, CHEN Rong-shou, WANG Shan, PENG Wan-sheng, ZHOU Rui. Clinical efficacy of fiberoptic bronchoscopy alveolar lavage in the treatment of Mycoplasma pneumoniae lobar pneumonia in children[J]. Chinese Journal of General Practice, 2021, 19(7): 1138-1141. doi: 10.16766/j.cnki.issn.1674-4152.002005
Citation: LU Bao-xia, CHEN Rong-shou, WANG Shan, PENG Wan-sheng, ZHOU Rui. Clinical efficacy of fiberoptic bronchoscopy alveolar lavage in the treatment of Mycoplasma pneumoniae lobar pneumonia in children[J]. Chinese Journal of General Practice, 2021, 19(7): 1138-1141. doi: 10.16766/j.cnki.issn.1674-4152.002005
shu

Clinical efficacy of fiberoptic bronchoscopy alveolar lavage in the treatment of Mycoplasma pneumoniae lobar pneumonia in children

doi: 10.16766/j.cnki.issn.1674-4152.002005
  • 1.

    Department of Pediatrics, Lu'an Hospital Affiliated to Anhui Medical University (Lu'an People's Hospital), Lu'an, Anhui 237005, China

Funds:

 KJ2019A0365

  • Received Date: 2020-10-21
    Available Online: 2022-02-16
    Abstract
  •   Objective  To observe the clinical curative effect, inflammatory index and immunity changes of Mycoplasma pneumoniae (MP) lobar pneumonia in children after treatment with fiberoptic bronchoscope alveolar lavage.  Methods  Total 60 children with lobar pneumonia caused by MP infection in the Department of Pediatrics of Lu'an people's Hospital from April 2019 to September 2020 were selected and randomly divided into observation group and control group with 30 cases in each group. The control group was given conventional treatment of Mycoplasma pneumoniae, and the observation group was given bronchoalveolar lavage under fiberoptic bronchoscope on the basis of conventional treatment. The clinical efficacy (including hospitalization time, cough disappearance time, body temperature recovery time), inflammatory factor levels, cellular immunity and humoral immunity indexes were compared between the two groups.  Results  (1) After treatment, the results of chest CT reexamination in the observation group showed that the lung shadow completely disappeared in 18 cases, partially disappeared in 10 cases, no change in 2 cases, the observation group was significantly better than the control group, the difference was statistically significant (P < 0.05). (2) In the observation group, cough disappearance time[(4.89±1.74) d], fever time[(2.63±0.56) d] and hospitalization days[(7.45±1.68) d] were less than those in the control group[(6.33±1.33) d, (3.85±1.29) d, (9.90±1.32) d, P < 0.05]. (3) Two sets of laboratory indexes after treatment, the levels of WBC, PCT, IL-6, TNF -α, CD3+, CD4+, CD4+/CD8+, IgA、IgM、IgG in the observation group were significantly better than those in the control group (all P < 0.05).  Conclusion  Bronchoalveolar lavage under fiberoptic bronchoscopy in the treatment of Mycoplasma pneumoniae lobar pneumonia can significantly improve the clinical efficacy, reduce inflammatory reaction, and accelerate the recovery of children's immunity.

     

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    • References(20)
  • [1]
    张同强, 郭伟, 周彩丽, 等. 支气管镜介入治疗儿童节段性肺炎支原体肺炎的效果及时机选择[J]. 山东医药, 2019, 59(4): 65-67. doi: 10.3969/j.issn.1002-266X.2019.04.017
    [2]
    戴天生, 郭辉, 张林. 儿童支原体肺炎肺部影像学特征及临床分析[J]. 临床医药实践, 2020, 29(9): 687-690. https://www.cnki.com.cn/Article/CJFDTOTAL-SXLC202009016.htm
    [3]
    陈先平, 王娟, 洪岩, 等. 肺炎支原体肺炎患儿MA耐药的危险因素分析及治疗建议[J]. 临床肺科杂志, 2020, 25(9): 1385-1388. doi: 10.3969/j.issn.1009-6663.2020.09.021
    [4]
    HYUNJU L, KI WOOK Y, HOAN JONG L, et al. Antimicrobial therapy of macrolide-resistant Mycoplasma pneumoniae pneumonia in children[J]. Expert Rev Anti Infect Ther, 2018, 16(1): 23-34. doi: 10.1080/14787210.2018.1414599
    [5]
    王琳. 肺炎支原体肺炎患儿肺炎支原体免疫球蛋白M抗体阳性显现时间的意义分析[J]. 中国现代药物应用, 2020, 14(16): 54-56. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY202016023.htm
    [6]
    LIU L, WANG Y, SUN J. Case report: Clinical and immunological features of a chinese cohort with mycoplasma-induced rash and mucositis[J]. Front Pediatr, 2020, 8: 402. doi: 10.3389/fped.2020.00402
    [7]
    李洁, 周浩泉, 胡嫚. 影像学不同表现的儿童肺炎支原体肺炎的临床特征[J]. 临床肺科杂志, 2020, 25(7): 1041-1045. doi: 10.3969/j.issn.1009-6663.2020.07.015
    [8]
    HUANG L, HUANG X, JIANG W, et al. Independent predictors for longer radiographic resolution in patients with refractory Mycoplasma pneumoniae pneumonia: A prospective cohort study[J]. BMJ Open, 2018, 8(12): e023719. doi: 10.1136/bmjopen-2018-023719
    [9]
    付红敏, 聂文莎. 难治性肺炎支原体肺炎诊治中应关注的问题[J]. 中华实用儿科临床杂志, 2018, 33(12): 891-894. doi: 10.3760/cma.j.issn.2095-428X.2018.12.004
    [10]
    林炜, 邱彬玮, 吴炽勇. 纤维支气管镜检查+肺泡灌洗术对小儿肺炎合并肺不张的诊疗作用[J]. 黑龙江医药科学, 2016, 39(6): 109-112. doi: 10.3969/j.issn.1008-0104.2016.06.047
    [11]
    WANG L, LU S, FENG Z. The early examination of combined serum and imaging data under flexible fiberoptic bronchoscopy as a novel predictor for refractory Mycoplasma pneumoniae pneumonia diagnosis[J]. Medicine (Baltimore), 2017, 96(50): e9364. doi: 10.1097/MD.0000000000009364
    [12]
    华军. 儿童难治性肺炎支原体肺炎发生塑型性支气管炎的危险因素分析[J]. 中华实用儿科临床杂志, 2019, 34(16): 1219-1222. doi: 10.3760/cma.j.issn.2095-428X.2019.16.006
    [13]
    刘奇, 郭宏丽. 支原体肺炎患儿血清PCT、CRP、T淋巴细胞亚群和免疫球蛋白的变化及意义[J]. 海南医学2020, 31(11): 1408-1411. doi: 10.3969/j.issn.1003-6350.2020.11.014
    [14]
    杜莉, 陈亮, 卓越, 等. PCT、sTREM-1、SPA和sICAM-1在支原体肺炎患儿中的检测价值[J]. 国际检验医学杂志, 2020, 41(3): 368-371. doi: 10.3969/j.issn.1673-4130.2020.03.030
    [15]
    邓建萍, 周卫芳, 孙旦, 等. MiR-49 2、IL-6在肺炎支原体免疫发病机制的作用研究[J]. 右江民族医学院学报, 2018, 40(5): 429-432. doi: 10.3969/j.issn.1001-5817.2018.05.007
    [16]
    王亚洲, 何鹏, 王丹虹, 等. 儿童支原体肺炎感染Th17/Treg平衡及IL-6/STAT3、IL-2/STAT5通路影响[J]. 中华医院感染学杂志, 2020, 30(7): 1043-1047. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY202007019.htm
    [17]
    杨涛. 肺炎支原体肺炎患儿血清中IL-5、IL-18及TNF-α水平及其与病情严重程度的关系[J]. 中外医学研究, 2018, 16(23): 12-14. https://www.cnki.com.cn/Article/CJFDTOTAL-YJZY201823005.htm
    [18]
    梁导艳, 郭春艳, 封青, 等. 肺炎支原体感染患儿视黄醇结合蛋白和T细胞亚群的变化及意义[J]. 中国实验诊断学, 2018, 22(12): 2053-2056. doi: 10.3969/j.issn.1007-4287.2018.12.004
    [19]
    吕静. 小儿肺炎支原体肺炎细胞免疫和体液免疫指标检测的临床价值[J]. 实用临床医药杂志, 2019, 23(6): 107-109. https://www.cnki.com.cn/Article/CJFDTOTAL-XYZL201906029.htm
    [20]
    陈育华, 周碧云, 梁斯锶, 等. 肺炎支原体感染患儿机体免疫功能分析[J]. 辽宁医学杂志, 2019, 33(6): 23-27. https://www.cnki.com.cn/Article/CJFDTOTAL-LNYX201906009.htm
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