Volume 19 Issue 8
Aug.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(8): 1287-1291
HUANG Liu, DAI Xinyu, TIAN Xue, YAO Jingqing, DAI Yue, LI Yunlao. Correlation between ApoE genotype and carotid atherosclerosis and cerebral infarction[J]. Chinese Journal of General Practice, 2021, 19(8): 1287-1291. doi: 10.16766/j.cnki.issn.1674-4152.002042
Citation: HUANG Liu, DAI Xinyu, TIAN Xue, YAO Jingqing, DAI Yue, LI Yunlao. Correlation between ApoE genotype and carotid atherosclerosis and cerebral infarction[J]. Chinese Journal of General Practice, 2021, 19(8): 1287-1291. doi: 10.16766/j.cnki.issn.1674-4152.002042
shu

Correlation between ApoE genotype and carotid atherosclerosis and cerebral infarction

doi: 10.16766/j.cnki.issn.1674-4152.002042
  • 1.

    Department of General Medicine, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, China

Funds:

 QNRC2016677

 SPOCYB201913

  • Received Date: 2020-08-17
    Available Online: 2022-02-16
    Abstract
  •   Objective  To study the correlation between apolipoprotein E (ApoE) genotype and the stability and location of carotid atherosclerotic plaque and cerebral infarction.  Methods  Total 275 patients from the Second Affiliated Hospital of Nanjing Medical University from January 1, 2019 to December 31, 2019 were divided into three groups according to the results of carotid ultrasound examinations: control group (88 cases), stable plaque group (71 cases) and unstable plaque group (116 cases). The ApoE genotype and blood lipid were determined. Patients with carotid atherosclerosis were inspected using head MRI. CAS patients were divided into the cerebral infarction group and no cerebral infarction group according to the MRI results.  Results  (1) The frequencies of ε2, ε3 and ε4 genes in the population were 10.7%, 78.2% and 11.1%, respectively, which conform to the law of genetic balance. (2) Significant differences were observed in the genotype distribution (P=0.008) between the unstable plaque group and the control group, and ε3/ε4 genotype (OR=3.115, 95% CI: 1.314-7.388) was more likely to lead to unstable plaques than the ε3/ε3 genotype. (3) The ApoE genotype had no significant relationship with the location of carotid plaque (χ2=3.190, P=0.527). (4) ε2 carriers (χ2=4.285, P=0.038) were less likely to have cerebral infarction than non- ε2 carriers with carotid atherosclerosis. (5) The ε2 allele was a protective factor for cerebral infarction in CAS patients after adjusting for age, sex, hypertension and diabetes (P=0.023, OR=0.352, 95% CI: 0.144-0.865).  Conclusion  The ε3/ε4 genotype may be a risk factor for the formation of unstable carotid atherosclerotic plaque. The ApoE genotype is not related to the location of carotid atherosclerotic plaque. The ε2 allele is a protective factor for cerebral infarction in CAS patients.

     

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