Volume 19 Issue 8
Aug.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(8): 1326-1329
LIN Yang, MIN Hong, ZHOU Hao-quan, CHEN Ming-wu, PAN Jia-hua. Influencing factors analysis of intracranial hemorrhage in premature infants[J]. Chinese Journal of General Practice, 2021, 19(8): 1326-1329. doi: 10.16766/j.cnki.issn.1674-4152.002052
Citation: LIN Yang, MIN Hong, ZHOU Hao-quan, CHEN Ming-wu, PAN Jia-hua. Influencing factors analysis of intracranial hemorrhage in premature infants[J]. Chinese Journal of General Practice, 2021, 19(8): 1326-1329. doi: 10.16766/j.cnki.issn.1674-4152.002052
shu

Influencing factors analysis of intracranial hemorrhage in premature infants

doi: 10.16766/j.cnki.issn.1674-4152.002052

  • Department of Pediatrics, the First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, Hefei, Anhui 230001, China

Funds:

 1804e03020323

  • Received Date: 2020-12-15
    Available Online: 2022-02-16
    Abstract
  •   Objective  Intracranial hemorrhage is a common complication in premature infants, which can leave different degrees of neurological sequelae. The purpose of this study was to investigate the high risk factors of intracranial hemorrhage in premature infants and provide theoretical basis for early intervention.   Methods   A total of 299 preterm infants who were admitted to the Neonatal Intensive Care Unit (NICU) of the First Affiliated Hospital of University of Science and Technology of China during January 2019 and December 2020. Total 114 preterm infants with intracranial hemorrhage were selected as study group, and other 185 premature infants without intracranial hemorrhage at the same period were selected as control group. Single factor and multivariate logistic regression analysis were used to identify risk factors for intracranial hemorrhage.   Results   Single factor analysis indicated pregnancy induced hypertension, late gestation infection, premature rupture of membranes, gestational age, birth weight, vaginal delivery, amniotic fluid pollution, 1 minute Apgar score, 5 minute Apgar score, NRDS (neonatal respiratory distress syndrome) and mechanical ventilation associated with the development of intracranial hemorrhage in preterm neonates (the chi square values were 4.376, 7.205, 5.042, 16.194, 15.982, 13.320, 4.859, 31.988, 25.855, 36.436, 29.262, all P < 0.05). Multivariate logistic regression analysis showed vaginal delivery, 1 minute Apgar score and NRDS were independent risk factors for intracranial hemorrhage (all P < 0.05).   Conclusion   Intracranial hemorrhage in premature infants is related to many factors, such as pregnancy induced hypertension, late gestation infection, premature rupture of membranes, gestational age, birth weight, vaginal delivery, amniotic fluid pollution, 1 minute Apgar score, 5 minute Apgar score, NRDS and mechanical ventilation, so comprehensive evaluation, early diagnosis and early treatment should be carried out in clinical work.

     

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