Volume 19 Issue 9
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(9): 1480-1483
LIU Jiao, FANG Ru-meng, WANG Tao, LI Zhi-jun. Analysis of clinical features and prognosis of antineutrophil cytoplasmic antibody with infection[J]. Chinese Journal of General Practice, 2021, 19(9): 1480-1483. doi: 10.16766/j.cnki.issn.1674-4152.002091
Citation: LIU Jiao, FANG Ru-meng, WANG Tao, LI Zhi-jun. Analysis of clinical features and prognosis of antineutrophil cytoplasmic antibody with infection[J]. Chinese Journal of General Practice, 2021, 19(9): 1480-1483. doi: 10.16766/j.cnki.issn.1674-4152.002091
shu

Analysis of clinical features and prognosis of antineutrophil cytoplasmic antibody with infection

doi: 10.16766/j.cnki.issn.1674-4152.002091
  • 1.

    Department of Rheumatology and Immunology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 2018jyxm0832

  • Received Date: 2021-02-17
    Available Online: 2022-02-15
    Abstract
  •   Objective  To analyse the clinical characteristics of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) co-infection and to explore the main risk factors that affect the occurrence of infection and the impact of infection on the prognosis of patients.   Methods  A retrospective analysis was conducted on 118 AAV patients admitted to our hospital in the past 6 years. The patients were divided into the infected group (72 cases) and non-infected group (46 cases). The clinical data of the two groups were compared, and the clinical characteristics of co-infection were analysed. Single factor analysis was used to analyze the risk factors of infection. Then, logistic regression analysis was used to explore the independent risk factors that affect the occurrence of infection. The patient's survival curve was drawn, and the impact of infection on patient's prognosis was explored.   Results  About 61.02% AAV patients had co-infection, fever, cough and sputum, malaise, muscle aches and severely increased ESR and CRP. significant increase in the infected group. Univariate analysis showed that there was significant difference between the two groups in advanced age, increased white blood cell count, decreased lymphocyte count, reduced haemoglobin, reduced albumin, increased C-reactive protein, increased erythrocyte sedimentation rate, electrolyte disturbances (decreased serum sodium ion concentration, serum chloride ion concentration, serum potassium ion concentration), higher BVAS score, use of cyclophosphamide. Multivariate analysis showed that decreased lymphocyte count and decreased serum potassium ion concentration were independent risk factors affecting infection in AAV patients; co-infection could significantly shorten the survival period of patients.   Conclusion  AAV is prone to co-infection, with respiratory infections being the most common. Multiple risk factors often lead to infection in AAV patients, amongst which decreased lymphocyte count and serum potassium ion concentration are independent risk factors for co-infection. Infection can accelerate the death of patients. Active prevention and treatment of infection can improve the prognosis of AAV patients.

     

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