Analysis of clinical features and prognosis of antineutrophil cytoplasmic antibody with infection

LIU Jiao; FANG Ru-meng; WANG Tao; LI Zhi-jun

doi:10.16766/j.cnki.issn.1674-4152.002091

Volume 19 Issue 9

Sep. 2021

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Chinese Journal of General Practice > 2021 > 19(9): 1480-1483

LIU Jiao, FANG Ru-meng, WANG Tao, LI Zhi-jun. Analysis of clinical features and prognosis of antineutrophil cytoplasmic antibody with infection[J]. Chinese Journal of General Practice, 2021, 19(9): 1480-1483. doi: 10.16766/j.cnki.issn.1674-4152.002091

Citation:

LIU Jiao, FANG Ru-meng, WANG Tao, LI Zhi-jun. Analysis of clinical features and prognosis of antineutrophil cytoplasmic antibody with infection[J]. Chinese Journal of General Practice, 2021, 19(9): 1480-1483. doi: 10.16766/j.cnki.issn.1674-4152.002091

Citation:

PDF( 1174 KB)

Analysis of clinical features and prognosis of antineutrophil cytoplasmic antibody with infection

doi: 10.16766/j.cnki.issn.1674-4152.002091

LIU Jiao¹
, FANG Ru-meng¹
, WANG Tao^{1, 2}
, LI Zhi-jun^{1, 2
,
,}

1.
Department of Rheumatology and Immunology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

2018jyxm0832

Received Date: 2021-02-17
Available Online: 2022-02-15

Abstract

Abstract

Objective To analyse the clinical characteristics of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) co-infection and to explore the main risk factors that affect the occurrence of infection and the impact of infection on the prognosis of patients. Methods A retrospective analysis was conducted on 118 AAV patients admitted to our hospital in the past 6 years. The patients were divided into the infected group (72 cases) and non-infected group (46 cases). The clinical data of the two groups were compared, and the clinical characteristics of co-infection were analysed. Single factor analysis was used to analyze the risk factors of infection. Then, logistic regression analysis was used to explore the independent risk factors that affect the occurrence of infection. The patient's survival curve was drawn, and the impact of infection on patient's prognosis was explored. Results About 61.02% AAV patients had co-infection, fever, cough and sputum, malaise, muscle aches and severely increased ESR and CRP. significant increase in the infected group. Univariate analysis showed that there was significant difference between the two groups in advanced age, increased white blood cell count, decreased lymphocyte count, reduced haemoglobin, reduced albumin, increased C-reactive protein, increased erythrocyte sedimentation rate, electrolyte disturbances (decreased serum sodium ion concentration, serum chloride ion concentration, serum potassium ion concentration), higher BVAS score, use of cyclophosphamide. Multivariate analysis showed that decreased lymphocyte count and decreased serum potassium ion concentration were independent risk factors affecting infection in AAV patients; co-infection could significantly shorten the survival period of patients. Conclusion AAV is prone to co-infection, with respiratory infections being the most common. Multiple risk factors often lead to infection in AAV patients, amongst which decreased lymphocyte count and serum potassium ion concentration are independent risk factors for co-infection. Infection can accelerate the death of patients. Active prevention and treatment of infection can improve the prognosis of AAV patients.
- Anti-neutrophil cytoplasmic antibody-associated vasculitis,
- Infection,
- Risk factors,
- Prognosis

FullText(HTML)

References(15)

References

[1]	PAGNOUX C. Updates in ANCA-associated vasculitis[J]. Eur J Rheumatol, 2016, 3(3): 122-133. doi: 10.5152/eurjrheum.2015.0043
[2]	SCOTT J, HARTNETT J, MOCKLER D, et al. Environmental risk factors associated with ANCA associated vasculitis: A systematic mapping review[J]. Autoimmun Rev, 2020, 19(11): 102660. doi: 10.1016/j.autrev.2020.102660
[3]	ADDY C, DORAN G, JONES A L, et al. Microscopic polyangiitis secondary to mycobacterium abscessus in a patient with bronchiectasis: A case report[J]. BMC Pulm Med, 2018, 18(1): 170. doi: 10.1186/s12890-018-0732-3
[4]	YANG L, XIE H L, LIU Z Z, et al. Risk factors for infectious complications of ANCA-associated vasculitis: A cohort study[J]. BMC Nephrol, 2018, 19(1): 138. doi: 10.1186/s12882-018-0933-2
[5]	MCGREGOR J G, NEGRETE-LOPEZ R, POULTON C J, et al. Adverse events and infectious burden, microbes and temporal outline from immunosuppressive therapy in antineutrophil cytoplasmic antibody-associated vasculitis with native renal function[J]. Nephrol Dial Transpl, 2015, 30(1): i171-i181. http://smartsearch.nstl.gov.cn/paper_detail.html?id=d46a0b285ac021c6a50021dc380a3e1b
[6]	HARISÁ H, POLNER K, ARÁNYI J, et al. Simple, Readily available clinical indices predict early and late mortality among patients with ANCA-associated vasculitis[J]. BMC Nephrol, 2017, 18(1): 76. doi: 10.1186/s12882-017-0491-z
[7]	THOMAS K, VASSILOPOULOS D. Infections and vasculitis[J]. Curr Opin Rheumatol, 2017, 29(1): 17-23. doi: 10.1097/BOR.0000000000000348
[8]	SCHIEFERMUELLER J, ALAOUR B, CALVER A, et al. Lesson of the month 1: Beware the atypical presentation: Eosinophilic granulomatosis with polyangiitis presenting as acute coronary syndrome[J]. Clin Med, 2017, 17(2): 180-182. doi: 10.7861/clinmedicine.17-2-180
[9]	ZHANG R, WANG S Y, ZHANG M, et al. Hyponatremia in patients with chronic kidney disease[J]. Hemodial Int, 2017, 21(1): 3-10. doi: 10.1111/hdi.12447
[10]	XU P C, TONG Z Y, CHEN T, et al. Hypoalbuminaemia in antineutrophil cytoplasmic antibody-associated vasculitis: Incidence and significance[J]. Clin Exp Rheumatol, 2018, 36(4): 603-611. http://www.ncbi.nlm.nih.gov/pubmed/29352844
[11]	袁瑞丽, 杨云娇, 李菁. 抗中性粒细胞胞浆抗体相关性血管炎感染患者淋巴细胞及CD4⁺ T细胞减少与死亡的相关性[J]. 中华临床免疫和变态反应杂志, 2020, 14(2): 49-54. https://www.cnki.com.cn/Article/CJFDTOTAL-OZHL202002007.htm
[12]	JENNETTE J C, NACHMAN P H. ANCA glomerulonephritis and vasculitis[J]. Clin J Am Soc Nephrol, 2017, 12(10): 1680-1691. doi: 10.2215/CJN.02500317
[13]	SHI L. Anti-neutrophil cytoplasmic antibody-associated vasculitis: prevalence, treatment, and outcomes[J]. Rheumatol Int, 2013, 37(11): 1779-1788. http://www.onacademic.com/detail/journal_1000040080547210_7043.html
[14]	JONES R B, HIEMSTRA T F, BALLARIN J, et al. Mycophenolate mofetil versus cyclophosphamide for remission induction in anca-associated vasculitis: A randomised, non-inferiority trial[J]. Ann Rheum Dis, 2019, 78(3): 399-405. doi: 10.1136/annrheumdis-2018-214245
[15]	MARTÍNEZ-MARTÍNEZ M U, OOSTDAM H V, ABUD-MENDOZA C. Diffuse alveolar hemorrhage in autoimmune diseases[J]. Curr Rheumatol Rep, 2017, 19(5): 27. doi: 10.1007/s11926-017-0651-y

Relative Articles

[1]	WANG Runping, ZHENG Xiaofen, CHEN Yingqiu, CHEN Aiwu, JIN Zhizhi, LI Yuxi. Risk factors and preventive nursing measures of acute leukaemia complicated with respiratory tract infection in children[J]. Chinese Journal of General Practice, 2023, 21(3): 522-525. doi: 10.16766/j.cnki.issn.1674-4152.002922
[2]	LIU Lei, LUO Guiquan, LIU Yijun, LI Xiaoping, REN Hongqiang. Risk factors and long-term prognosis of malignant arrhythmia in elderly patients with dilated cardiomyopathy[J]. Chinese Journal of General Practice, 2023, 21(6): 958-961. doi: 10.16766/j.cnki.issn.1674-4152.003024
[3]	WANG Dao-xin, LIU Nan, SHI Ze-yuan, DING Nan-nan, FENG Chun-qian, ZHAO Wen-li. A meta-analysis of status and risk factors of central venous catheter-associated bloodstream infection in ICU patients[J]. Chinese Journal of General Practice, 2022, 20(11): 1954-1959. doi: 10.16766/j.cnki.issn.1674-4152.002745
[4]	FAN Jing, HUANG Guan-wen, BAO Ji-wen, ZHANG Min-fang, ZHOU Wen-yan, WANG Qin, NI Zhao-hui, WANG Ling. Analysis of risk factors for the prognosis of IgA nephropathy[J]. Chinese Journal of General Practice, 2022, 20(5): 731-734. doi: 10.16766/j.cnki.issn.1674-4152.002441
[5]	YAO Xiao-qian, XU Tong-mei, XU Jing, YU Er-li, SHI Bei-tian, LIN Ning. Research of the characteristic of pathogenic bacteria and risk factors in intracranial infection after hypertensive cerebral hemorrhage[J]. Chinese Journal of General Practice, 2021, 19(2): 224-226. doi: 10.16766/j.cnki.issn.1674-4152.001773
[6]	ZHANG Li-ping, LOU Zhi-ping. Risk factors of cross-infection in orthodontic patients and predictive nursing intervention[J]. Chinese Journal of General Practice, 2021, 19(2): 320-323. doi: 10.16766/j.cnki.issn.1674-4152.001799
[7]	CHI Shui-jing, FENG Yi, LI Hui, YANG Yue, ZHAO Kai-feng, FAN Bo, ZHANG Le, TANG Guan-jie. Analysis of risk factors related to pneumonia after multidrug-resistant bacterial infection and exploration of control methodology[J]. Chinese Journal of General Practice, 2021, 19(4): 671-673, 701. doi: 10.16766/j.cnki.issn.1674-4152.001890
[8]	SONG Yang, XIA Bing, WU Yue-guang. Analysis of related clinical risk factors of lung infection in patients with lung cancer[J]. Chinese Journal of General Practice, 2021, 19(3): 354-357,462. doi: 10.16766/j.cnki.issn.1674-4152.001808
[9]	XU Qian-qian, LIU Bin-bin, CHEN Xue-xiang, SHEN Huai-yun. Analysis of preoperative risk factors of severe neonatal meconium aspiration syndrome[J]. Chinese Journal of General Practice, 2021, 19(1): 31-34. doi: 10.16766/j.cnki.issn.1674-4152.001722
[10]	CHEN Gang, HUANG Ming-wei, KONG Lai-fa, SHI Tao, FANG Hao. Analysis of etiology and risk factors of wound infection after closed pelvic fracture[J]. Chinese Journal of General Practice, 2020, 18(7): 1128-1130. doi: 10.16766/j.cnki.issn.1674-4152.001446
[11]	ZHOU Lian-lian, LI Fang, LI Mian-mian, CHEN Xiao-jian. Eperythrozoon infection and related infection factors in patients with tumors[J]. Chinese Journal of General Practice, 2019, 17(7): 1105-1108. doi: 10.16766/j.cnki.issn.1674-4152.000874
[12]	HE Jun, HUANG Bin. Characteristics and risk factors of postoperative infection in tibial fracture patients after plate fixation[J]. Chinese Journal of General Practice, 2019, 17(1): 70-72. doi: 10.16766/j.cnki.issn.1674-4152.000602
[13]	YE Hong-ying, YING Jun, FANG He-jing, HUANG Jian. Risk factors of pulmonary infection in chronic renal failure patients undergoing maintenance hemodialysis[J]. Chinese Journal of General Practice, 2018, 16(6): 932-934. doi: 10.16766/j.cnki.issn.1674-4152.000256
[14]	SHI Yan, FANG Ying, LI Yun-na, WANG Shi-qiang, LI Yan-fang, YIN Cui-ying. Risk factors analysis and nursing strategies of COPD patients with pulmonary fungal infection[J]. Chinese Journal of General Practice, 2018, 16(2): 309-312. doi: 10.16766/j.cnki.issn.1674-4152.000086
[15]	YANG Fan, CHEN Jun-liang, TONG Min-feng, ZHOU Ge-zhi, YUAN Jian-lie. Risk factors associated with intracranial infection after surgery for intraventricular hemorrhage[J]. Chinese Journal of General Practice, 2018, 16(9): 1435-1437. doi: 10.16766/j.cnki.issn.1674-4152.000392
[16]	LIN Xia, SUN Cheng-chao, ZHANG Xiang-yan, TU Shao-song, HUANG Jin-wei. Epidemiology and risk factors of Pseudomonas aeruginosa infection in patients with severe thoracic trauma and mechanical ventilation[J]. Chinese Journal of General Practice, 2017, 15(3): 518-520. doi: 10.16766/j.cnki.issn.1674-4152.2017.03.047
[18]	LI Xiao-qing, XU Qi-xia, PANG Ying-ying. Analysis of prognostic factors of pulmonary thromboembolism[J]. Chinese Journal of General Practice, 2017, 15(6): 1022-1026. doi: 10.16766/j.cnki.issn.1674-4152.2017.06.035
[19]	ZHENG Fei-xia, LIN Zhong-dong, YE Xiu-yun, SHI Xu-lai. Study on the risk factors of poor prognosis of infant purulent meningitis[J]. Chinese Journal of General Practice, 2017, 15(3): 460-462. doi: 10.16766/j.cnki.issn.1674-4152.2017.03.030
[20]	YANG Yu-ling, LI Ping, ZHANG Qiao-ping, LIN Shao-qin, MU Dong-mei. Risk factor analysis central venous catheter infection in neurosurgical patients[J]. Chinese Journal of General Practice, 2016, 14(12): 2037-2039,2146. doi: 10.16766/j.cnki.issn.1674-4152.2016.12.020

Supplements(0)

Cited By

Cited by

Periodical cited type(3)

1.	谌登珍，马强. 血清补体C1q、C3与中性粒细胞胞浆抗体相关性血管炎患者临床特征、病理类型及预后相关性研究. 陕西医学杂志. 2023(01): 105-109 .
2.	牛芳，唐素娟，尹振华. 富马酸比索洛尔片联合噻托溴铵粉雾剂雾化吸入治疗慢性阻塞性肺疾病急性加重期并发肺源性心脏病患者的疗效. 中国医师杂志. 2023(07): 1003-1007 .
3.	王红权，郑小艳，邹亮，梅振华，詹杰. 抗中性粒细胞胞浆抗体相关性血管炎合并自身免疫性溶血性贫血及噬血细胞综合征一例. 临床内科杂志. 2023(12): 856-857 .

Other cited types(1)

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1) / Tables(3)

Get Citation

PDF

XML

Article Metrics

Article views (322) PDF downloads(11)

Analysis of clinical features and prognosis of antineutrophil cytoplasmic antibody with infection

doi: 10.16766/j.cnki.issn.1674-4152.002091