Volume 19 Issue 9
Sep.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(9): 1510-1513
HU Yan-yan, PAN Jia-hua, ZHOU Hao-quan. Analysis of clinical and laboratory characteristics of infectious mononucleosis in children[J]. Chinese Journal of General Practice, 2021, 19(9): 1510-1513. doi: 10.16766/j.cnki.issn.1674-4152.002099
Citation: HU Yan-yan, PAN Jia-hua, ZHOU Hao-quan. Analysis of clinical and laboratory characteristics of infectious mononucleosis in children[J]. Chinese Journal of General Practice, 2021, 19(9): 1510-1513. doi: 10.16766/j.cnki.issn.1674-4152.002099
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Analysis of clinical and laboratory characteristics of infectious mononucleosis in children

doi: 10.16766/j.cnki.issn.1674-4152.002099

  • Department of Pediatrics, the First Hospital Affiliated of University of Science and Technology of China, Hefei, Anhui 230001, China

Funds:

 1804e03020323

  • Received Date: 2020-12-16
    Available Online: 2022-02-15
    Abstract
  •   Objective  To analyse the clinical characteristics and laboratory examination indicators of children with infectious mononucleosis (IM) and improve the understanding of clinicians.   Methods  The clinical data of 114 children with IM hospitalised in the First Affiliated Hospital of the University of Science and Technology of China from May 2019 to April 2020 were retrospectively analysed to summarise and analyse their clinical characteristics.   Results  The 114 patients included 66 males and 48 females. The male-to-female ratio was 1.375∶ 1. The age distribution was as follows: < 3 years old, 39 cases; 3-6 years old, 60 cases; >6 years old, 15 cases. The seasonal distribution was as follows: 34 cases in spring, 27 cases in summer, 36 cases in autumn and 17 cases in winter. The clinical manifestation was as follows: 107 cases of fever, 107 cases of pharyngitis, 93 cases of cervical lymph node enlargement, 41 cases of liver enlargement, 65 cases of spleen enlargement, 56 cases of eyelid oedema and 23 cases of rash. The total number of peripheral leukocytes ranged between 10×109/L and 20×109/L. The characteristics of laboratory tests were as follows: the lymphocyte ratio ranged between 50% and 70%, the prevalence of atypical lymphocytes in peripheral blood was 68.42%, a total of 59 cases had liver function impairment. The positive rate of capsid antigen IgM antibody was the highest. The positive rate of Epstein-Barr virus nucleic acid (EBV-DNA) in whole blood was 92.86%.   Conclusion  IM in children is more common in males and ages 3 to 6 years. The incidence rate is high in spring and autumn. The clinical symptoms include pneumonia and myocardial damage. Most of them have good prognosis. Capsid antigen IgM antibody detection combined with whole blood EBV-DNA detection can improve the positive detection rate and reduce clinical missed diagnosis and misdiagnosis.

     

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