Correlation between intestinal flora and clinical symptoms in patients with schizophrenia

WANG Zhong-xian; ZHANG Ai-guo; YAO Li-hui; CHENG Xia-long; CHENG Peng; ZHU Cui-zhen; SU Hong; ZHANG Xu-lai

doi:10.16766/j.cnki.issn.1674-4152.002104

Volume 19 Issue 9

Sep. 2021

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Article Navigation > Chinese Journal of General Practice > 2021 > 19(9): 1530-1534

WANG Zhong-xian, ZHANG Ai-guo, YAO Li-hui, CHENG Xia-long, CHENG Peng, ZHU Cui-zhen, SU Hong, ZHANG Xu-lai. Correlation between intestinal flora and clinical symptoms in patients with schizophrenia[J]. Chinese Journal of General Practice, 2021, 19(9): 1530-1534. doi: 10.16766/j.cnki.issn.1674-4152.002104

Citation:

WANG Zhong-xian, ZHANG Ai-guo, YAO Li-hui, CHENG Xia-long, CHENG Peng, ZHU Cui-zhen, SU Hong, ZHANG Xu-lai. Correlation between intestinal flora and clinical symptoms in patients with schizophrenia[J]. Chinese Journal of General Practice, 2021, 19(9): 1530-1534. doi: 10.16766/j.cnki.issn.1674-4152.002104

Citation:

WANG Zhong-xian, ZHANG Ai-guo, YAO Li-hui, CHENG Xia-long, CHENG Peng, ZHU Cui-zhen, SU Hong, ZHANG Xu-lai. Correlation between intestinal flora and clinical symptoms in patients with schizophrenia[J]. Chinese Journal of General Practice, 2021, 19(9): 1530-1534. doi: 10.16766/j.cnki.issn.1674-4152.002104

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Correlation between intestinal flora and clinical symptoms in patients with schizophrenia

doi: 10.16766/j.cnki.issn.1674-4152.002104

WANG Zhong-xian^{1, 2}
, ZHANG Ai-guo^{1, 2}
, YAO Li-hui^{1, 2}
, CHENG Xia-long^{1, 2}
, CHENG Peng^{1, 2}
, ZHU Cui-zhen^{1, 2}
, SU Hong³
, ZHANG Xu-lai^{1, 2
,
,}

1.
Anhui Metal Health Center, Hefei, Anhui 230022, China

Funds:

81773518

J2018Y05

Received Date: 2020-06-15
Available Online: 2022-02-15

Abstract

Abstract

Objective This study aimed to explore the correlation between the structural characteristics of schizophrenia flora and clinical symptoms. Methods Patients who were diagnosed with schizophrenia in the fourth hospital in Hefei from October 2018 to June 2019 were included in this study: 32 patients in the acute stage (group A), 30 in the remission stage (group B) and 34 in the healthy control group (group C). The 16SrRNA technique was used to analyse the difference of bacterial flora and its correlation with clinical symptoms. Results (1) The abundance of other mycobacteria in group A was higher than that in group C (F=2.575, P=0.017), whereas the abundance of thiobacillus in group A was lower than that in group C (F=3.940, P=0.023). The abundance of macrococcidia in groups A and B was higher than that of group C (F=11.720, P < 0.001), and the abundance of trichoderma and coprococcus in groups A and B was lower than that of group C (F=4.279、3.670, all P < 0.05). The abundance of Bacteroidetes, haemophilus and Clostridium tyrosine in group A was higher than that in group B (F=2.977, 4.840; F=2.655, P < 0.05), and the abundance of vibrio succinate was lower than that of group B (F=6.190, P=0.003). (2) Microbacilli were negatively correlated with depression factors (r=-0.269, P=0.034). Macrosomonas was positively correlated with the total PANSS score (r=0.291, P=0.022). Bacteroidetes was positively correlated with positive factors (r=0.282, P=0.029). Conclusion The structural changes of the microflora in the acute and remission stages of schizophrenia and the relative abundance of some microflora were correlated with clinical symptoms.
- Schizophrenia,
- Intestinal flora,
- High-throughput sequencing,
- Clinical symptoms

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Correlation between intestinal flora and clinical symptoms in patients with schizophrenia

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