Analysis of the distribution characteristics and drug resistance of pathogenic bacteria of blood infection

SHI Ming-Mei; GUO Pu

doi:10.16766/j.cnki.issn.1674-4152.002107

Volume 19 Issue 9

Sep. 2021

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Article Navigation > Chinese Journal of General Practice > 2021 > 19(9): 1542-1544

SHI Ming-Mei, GUO Pu. Analysis of the distribution characteristics and drug resistance of pathogenic bacteria of blood infection[J]. Chinese Journal of General Practice, 2021, 19(9): 1542-1544. doi: 10.16766/j.cnki.issn.1674-4152.002107

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SHI Ming-Mei, GUO Pu. Analysis of the distribution characteristics and drug resistance of pathogenic bacteria of blood infection[J]. Chinese Journal of General Practice, 2021, 19(9): 1542-1544. doi: 10.16766/j.cnki.issn.1674-4152.002107

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Analysis of the distribution characteristics and drug resistance of pathogenic bacteria of blood infection

doi: 10.16766/j.cnki.issn.1674-4152.002107

SHI Ming-Mei^{1
,
,}
, GUO Pu²

1.
Clinical Laboratory, Maanshan Shiqiye Hospital, Maanshan, Anhui 243000, China

Funds:

1804h08020256

Received Date: 2020-05-30
Available Online: 2022-02-15

Abstract

Abstract

Objective To provide reference and support for clinical diagnosis and treatment of bloodstream infections, a retrospective analysis was performed to determine the distribution characteristics of pathogens of bloodstream infections and the drug resistance of common bacteria. Methods The positive blood culture specimens of outpatients and inpatients in our hospital from July 2018 to July 2019 were included in the study. Duplicate strains of the same patient were eliminated, as these confirmed that the contaminating bacteria were eliminated. The pathogen of bloodstream infection was isolated according to the unified program, and the blood culture specimens were cultured, identified and analysed for drug sensitivity. Results According to statistics, 708 non-repetitive pathogenic bacteria were collected, including 326 Gram-positive bacteria (46.05%), 373 Gram-negative bacteria (52.68%) and 9 fungi (1.27%). The first five pathogens were coagulase-negative Staphylococcus, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa. The results of drug sensitivity analysis showed that Staphylococcus and Enterococcus were 100% sensitive to vancomycin, linezolid and teicoplanin, and their drug resistance rates to erythromycin were higher than 70%. The detection rates of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum β-lactamase were 47.02% and 30.15%, respectively. The drug resistance rates to ceftriaxone and ceftazidime were 30%-50%. The resistance rates of Pseudomonas aeruginosa to tested antibiotics were less than 30%, and the resistance rates of all isolated Gram-negative bacteria to carbapenems were less than 5%. Conclusion Blood culture pathogens isolated from the bacteria spectrum are many and varied. Considering the significant resistance of these pathogens to some drugs, clinicians should promote blood culture consciousness and strengthen the monitoring of blood culture pathogen distribution and antimicrobial sensitivity as soon as possible. Diagnosis and treatment of patients need to be individualized as they vary from person to person and should be performed in accordance with the rational use of antimicrobial agents in consideration of pathogen susceptibility. Clinicians need to strengthen the detection of drug resistance situation and changes thereof to guide clinical rational drug use, effective control of blood flow to the emergence and spread of drug-resistant bacterial infection.
- Bloodstream infection,
- Pathogenic bacteria,
- Resistance analysis

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References

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Analysis of the distribution characteristics and drug resistance of pathogenic bacteria of blood infection

doi: 10.16766/j.cnki.issn.1674-4152.002107