Analysis of the distribution characteristics and drug resistance of pathogenic bacteria of blood infection

SHI Ming-Mei; GUO Pu

doi:10.16766/j.cnki.issn.1674-4152.002107

Volume 19 Issue 9

Sep. 2021

Turn off MathJax

Article Contents

Article Navigation > Chinese Journal of General Practice > 2021 > 19(9): 1542-1544

SHI Ming-Mei, GUO Pu. Analysis of the distribution characteristics and drug resistance of pathogenic bacteria of blood infection[J]. Chinese Journal of General Practice, 2021, 19(9): 1542-1544. doi: 10.16766/j.cnki.issn.1674-4152.002107

Citation:

SHI Ming-Mei, GUO Pu. Analysis of the distribution characteristics and drug resistance of pathogenic bacteria of blood infection[J]. Chinese Journal of General Practice, 2021, 19(9): 1542-1544. doi: 10.16766/j.cnki.issn.1674-4152.002107

Citation:

PDF( 1136 KB)

Analysis of the distribution characteristics and drug resistance of pathogenic bacteria of blood infection

doi: 10.16766/j.cnki.issn.1674-4152.002107

SHI Ming-Mei^{1
,
,}
, GUO Pu²

1.
Clinical Laboratory, Maanshan Shiqiye Hospital, Maanshan, Anhui 243000, China

Funds:

1804h08020256

Received Date: 2020-05-30
Available Online: 2022-02-15

Abstract

Abstract

Objective To provide reference and support for clinical diagnosis and treatment of bloodstream infections, a retrospective analysis was performed to determine the distribution characteristics of pathogens of bloodstream infections and the drug resistance of common bacteria. Methods The positive blood culture specimens of outpatients and inpatients in our hospital from July 2018 to July 2019 were included in the study. Duplicate strains of the same patient were eliminated, as these confirmed that the contaminating bacteria were eliminated. The pathogen of bloodstream infection was isolated according to the unified program, and the blood culture specimens were cultured, identified and analysed for drug sensitivity. Results According to statistics, 708 non-repetitive pathogenic bacteria were collected, including 326 Gram-positive bacteria (46.05%), 373 Gram-negative bacteria (52.68%) and 9 fungi (1.27%). The first five pathogens were coagulase-negative Staphylococcus, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa. The results of drug sensitivity analysis showed that Staphylococcus and Enterococcus were 100% sensitive to vancomycin, linezolid and teicoplanin, and their drug resistance rates to erythromycin were higher than 70%. The detection rates of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum β-lactamase were 47.02% and 30.15%, respectively. The drug resistance rates to ceftriaxone and ceftazidime were 30%-50%. The resistance rates of Pseudomonas aeruginosa to tested antibiotics were less than 30%, and the resistance rates of all isolated Gram-negative bacteria to carbapenems were less than 5%. Conclusion Blood culture pathogens isolated from the bacteria spectrum are many and varied. Considering the significant resistance of these pathogens to some drugs, clinicians should promote blood culture consciousness and strengthen the monitoring of blood culture pathogen distribution and antimicrobial sensitivity as soon as possible. Diagnosis and treatment of patients need to be individualized as they vary from person to person and should be performed in accordance with the rational use of antimicrobial agents in consideration of pathogen susceptibility. Clinicians need to strengthen the detection of drug resistance situation and changes thereof to guide clinical rational drug use, effective control of blood flow to the emergence and spread of drug-resistant bacterial infection.
- Bloodstream infection,
- Pathogenic bacteria,
- Resistance analysis

FullText(HTML)

References(21)

References

[1]	周梦兰, 杨启文, 于淑颖, 等. 血流感染流行病学研究进展[J]. 中国感染与化疗杂志, 2019, 19(2): 212-217. https://www.cnki.com.cn/Article/CJFDTOTAL-KGHL201902021.htm
[2]	HUERTA L E, RICE T W. Pathologic difference between sepsis and bloodstream infections[J]. J Appl Lab Med, 2019, 3(4): 654-663. doi: 10.1373/jalm.2018.026245
[3]	韩如慧, 金美娟, 乔美珍, 等. 血液肿瘤患者经外周静脉置入中心静脉导管相关血流感染的影响因素分析[J]. 中国感染与化疗杂志, 2018, 18(2): 150-155. https://www.cnki.com.cn/Article/CJFDTOTAL-KGHL201802008.htm
[4]	LAMY B, SUNDQVIST M, IDELEVICH E A, et al. Bloodstream infections-Standard and progress in pathogen diagnostics[J]. Clin Microbiol Infect, 2020, 26(2): 142-150. doi: 10.1016/j.cmi.2019.11.017
[5]	中华人民共和国国家卫生和计划生育委员会. WS/T503-2017临床微生物实验室血培养操作规范[S]. 2017.
[6]	Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing[S]. 2019, M100-S29.
[7]	SAAD E J, BAENAS D F, BOISSEAU C S, et al. Characteristics of bloodstream infections in adult patients of two third level centers of Córdoba, Argentina[J]. Rev Fac Cien Med Univ Nac Cordoba, 2018, 75(3): 156-167. doi: 10.31053/1853.0605.v75.n3.19455
[8]	陈云波, 嵇金如, 应超群, 等. 2016至2017年全国血流感染细菌耐药监测(BRICS)报告[J]. 中华临床感染病杂志, 2020, 13(1): 42-43, 54.
[9]	陈国敏, 王东辰, 许会彬, 等. 3889份住院患者血培养病原菌分布及耐药性分析[J]. 中国抗生素杂志, 2019, 44(2): 266-269. doi: 10.3969/j.issn.1001-8689.2019.02.021
[10]	菅记涌, 解泽强, 全秀秀, 等. 血流感染病原菌分布及耐药性分析[J]. 中华医院感染学杂志, 2017, 27(3): 535-538. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201703016.htm
[11]	唐洪影, 胡志东, 李静, 等. 2014—2017年血培养常见病原菌的菌群分布及其耐药性变迁[J]. 中国抗生素杂志, 2018, 43(5): 566-571. doi: 10.3969/j.issn.1001-8689.2018.05.013
[12]	李保松, 纪冰, 安新业, 等. 2016—2017年滨州地区血流感染病原菌分布及其耐药性分析[J]. 滨州医学院学报, 2019, 42(6): 418-420, 423. https://www.cnki.com.cn/Article/CJFDTOTAL-BZYB201906006.htm
[13]	伍婷婷, 曾吉, 景小鹏, 等. 血培养分离凝固酶阴性葡萄球菌的临床意义[J]. 中华传染病杂志, 2018, 36(11): 661-664. https://www.cnki.com.cn/Article/CJFDTOTAL-KGHL200102007.htm
[14]	ASAAD A M, ANSAR QURESHI M, MUJEEB HASAN S. Clinical significance of coagulase-negative staphylococci isolates from nosocomial bloodstream infections[J]. Infect Dis(Lond), 2016, 48(5): 356-360. doi: 10.3109/23744235.2015.1122833
[15]	刘兆玮, 马科, 胡景玉, 等. 重症监护病房血流感染的危险因素及预后分析[J]. 中国感染与化疗杂志, 2019, 19(1): 12-17. https://www.cnki.com.cn/Article/CJFDTOTAL-KGHL201901004.htm
[16]	HATTORI H, MAEDA M, NAGATOMO Y, et al. Epidemiology and risk factors for mortality in bloodstream infections: A single-center retrospective study in Japan[J]. Am J Infect Control, 2018, 46(12): e75-e79.
[17]	陈倩倩, 宋缘缘, 唐洪影, 等. 2015—2018年血流感染病原菌菌群分布及耐药性分析[J]. 天津医科大学学报, 2020, 26(3): 271-275.
[18]	CHEN C H, LIN L C, CHANG Y J. Clinical and microbiological characteristics of vancomycin-resistant Enterococcus faecium bloodstream infection in Central Taiwan[J]. Medicine(Baltimore), 2017, 96(49): e9000.
[19]	叶小群, 杨青, 严平, 等. 耐万古霉素肠球菌血流感染相关因素分析[J]. 中华医院感染学杂志, 2018, 28(19): 2901-2904. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201819006.htm
[20]	张志军, 鹿麟, 牛法霞, 等. 耐碳青霉烯类肺炎克雷伯菌的耐药机制与分子流行病学特征[J]. 中国感染控制杂志, 2018, 17(9): 759-763. https://www.cnki.com.cn/Article/CJFDTOTAL-GRKZ201809003.htm
[21]	缪柯淳, 苏青青, 张新月, 等. 铜绿假单胞菌血流感染251例临床分析[J]. 中国感染与化疗杂志, 2018, 18(6): 568-573. https://www.cnki.com.cn/Article/CJFDTOTAL-KGHL201806002.htm

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Tables(3)

Get Citation

PDF

XML

Article Metrics

Article views (321) PDF downloads(8)

Analysis of the distribution characteristics and drug resistance of pathogenic bacteria of blood infection

doi: 10.16766/j.cnki.issn.1674-4152.002107

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Analysis of the distribution characteristics and drug resistance of pathogenic bacteria of blood infection

doi: 10.16766/j.cnki.issn.1674-4152.002107

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content