Volume 19 Issue 10
Oct.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(10): 1626-1628,1705
LAI Jia-cheng, HAN Yong-sheng. Relationship between lipoprotein-associated phospholipase A2 with degree of carotid atherosclerosis[J]. Chinese Journal of General Practice, 2021, 19(10): 1626-1628,1705. doi: 10.16766/j.cnki.issn.1674-4152.002127
Citation: LAI Jia-cheng, HAN Yong-sheng. Relationship between lipoprotein-associated phospholipase A2 with degree of carotid atherosclerosis[J]. Chinese Journal of General Practice, 2021, 19(10): 1626-1628,1705. doi: 10.16766/j.cnki.issn.1674-4152.002127
shu

Relationship between lipoprotein-associated phospholipase A2 with degree of carotid atherosclerosis

doi: 10.16766/j.cnki.issn.1674-4152.002127

  • Department of Emergency Medicine, Anhui Provincial Hospital Affiliated to Anhui Medical University ，Hefei ,Anhui 230001 ,China

Funds:

 81973314

 KFJ-STS-QYZD-184

 1804h08020291

 201903a07020027

  • Received Date: 2021-01-22
    Available Online: 2022-02-15
    Abstract
  •   Objective  To investigate the correlation and clinical significance of lipoprotein phospholipase A2 (Lp-PLA2) with the extent of atherosclerosis in carotid arteries.  Methods  A total of 227 patients admitted at Anhui Provincial Hospital from October 2019 to April 2020 were included in this study. Patients were divided into three groups according to the degree of carotid artery atherosclerosis, namely, control group (no significant carotid stenosis, n=58), carotid atherosclerosis group (carotid artery stenosis < 50%, n=119) and carotid stenosis group (carotid stenosis≥50%, n=50). According to whether there are new cardiovascular events, they were divided into no new event group (154 cases) and new event group (73 cases). The levels of Lp-PLA2 and other conventional indicators were detected in all subjects, and the relationship between their levels and degree of carotid atherosclerosis was analysed, and analyzing the factors associated with carotid atherosclerotic lesions using multiple linear regression models.  Results  Compared with the control group [(89.29±41.15) ng/mL], Lp-PLA2 was significantly increased in the carotid atherosclerosis group [(103.92±37.90) ng/mL] and carotid stenosis group [(121.96±41.27) ng/mL, all P < 0.05]. Lp-PLA2 in the new event group [(114.93±36.50) ng/mL] was significantly higher than that in the no new event group [(98.76±42.47) ng/mL, P < 0.05]. Linear regression analysis showed that Lp-PLA2 was an independent risk factor for carotid atherosclerosis.  Conclusion  Lp-PLA2 was correlated with the degree of carotid atherosclerosis. The serum Lp-PLA2 concentration increased with the gradual deepening of carotid atherosclerosis.

     

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