Volume 19 Issue 10
Oct.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(10): 1646-1649
XU Meng-ting, LING Yun-zhi, ZHANG Jing-jun, XU Hui. Effect of dexmedetomidine combined with different anaesthesia depth on postoperative delirium in elderly patients undergoing total hip replacement[J]. Chinese Journal of General Practice, 2021, 19(10): 1646-1649. doi: 10.16766/j.cnki.issn.1674-4152.002132
Citation: XU Meng-ting, LING Yun-zhi, ZHANG Jing-jun, XU Hui. Effect of dexmedetomidine combined with different anaesthesia depth on postoperative delirium in elderly patients undergoing total hip replacement[J]. Chinese Journal of General Practice, 2021, 19(10): 1646-1649. doi: 10.16766/j.cnki.issn.1674-4152.002132
shu

Effect of dexmedetomidine combined with different anaesthesia depth on postoperative delirium in elderly patients undergoing total hip replacement

doi: 10.16766/j.cnki.issn.1674-4152.002132
  • 1.

    Graduated School of Bengbu Medical College, Bengbu, Anhui 233000, China

Funds:

 KJ2019A0330

 BYKY18181

  • Received Date: 2020-12-25
    Available Online: 2022-02-15
    Abstract
  •   Objective  To investigate the effect of dexmedetomidine combined with different anaesthesia depth on postoperative delirium in elderly patients with total hip replacement.  Methods  A total of 96 elderly patients undergoing total hip arthroplasty in our hospital from December 2018 to May 2020 were selected and divided into three groups according to their bispectral index (BIS). The BIS values of groups A, B and C were 40-49 (n=32), 50-59 (n=35) and 60-69 (n=29), respectively. The degree of consciousness disturbance, serum neuron-specific enolase (NSE), serum S100β protein concentration and delirium were observed and compared amongst the three groups.  Results  The Mini-Mental State Examination (MMSE) scores of the three groups were significantly different (P < 0.05). The MMSE score of group B was higher than that of groups A and C (all P < 0.05), but no significant difference was observed between group A and group C (P>0.05). Compared with NSE and serum S100β protein concentration before operation, NSE and serum S100β protein concentration at 72 h after operation were significantly different amongst the three groups (all P < 0.05). NSE and serum S100β protein concentrations in group B were lower than those in groups A and C (all P < 0.05), but no difference was observed between group A and group C in terms of NSE and serum S100 β protein concentration (all P>0.05). Eight cases (25.00%), 1 case (2.86%) and 7 cases (24.14%) of delirium were observed in groups A, B and C within 72 h after operation, respectively. A significant difference was observed between the three groups (P < 0.05). The incidence of postoperative delirium in group B was lower than that in groups A and C (all P < 0.017), but no difference was observed between group A and group C (P>0.017).  Conclusion  Dexmedetomidine combined with anaesthesia depth range of 50-59 can not only effectively improve the NSE and serum S100β protein concentration, but also reduce the degree of postoperative consciousness disturbance and delirium in elderly patients undergoing total hip replacement.

     

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