Volume 19 Issue 10
Oct.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(10): 1677-1679
ZHANG Jie, WANG Qiong, CAO Hong-wei. Correlation between hypoglycaemia and cognitive dysfunction in elderly diabetic patients[J]. Chinese Journal of General Practice, 2021, 19(10): 1677-1679. doi: 10.16766/j.cnki.issn.1674-4152.002140
Citation: ZHANG Jie, WANG Qiong, CAO Hong-wei. Correlation between hypoglycaemia and cognitive dysfunction in elderly diabetic patients[J]. Chinese Journal of General Practice, 2021, 19(10): 1677-1679. doi: 10.16766/j.cnki.issn.1674-4152.002140
shu

Correlation between hypoglycaemia and cognitive dysfunction in elderly diabetic patients

doi: 10.16766/j.cnki.issn.1674-4152.002140

  • Department of Endocrinology and Metabolism, the First Affiliated Hospital of Air Force Military Medical University, Xi'an, Shaanxi 710032, China

Funds:

 2018YFC1309803

  • Received Date: 2020-12-27
    Available Online: 2022-02-15
    Abstract
  •   Objective  To explore the cognitive dysfunction in elderly diabetic patients with hypoglycaemia and to analyse the correlation between hypoglycaemia and cognitive dysfunction.  Methods  A total of 610 elderly diabetic patients admitted at our hospital from June 2019 to June 2020 were selected as the research subjects. The patients were divided into the severe hypoglycaemia group (n=24), mild hypoglycaemia group (n=277) and non-hypoglycaemia group (n=309). According to the frequency of hypoglycaemia, the patients were divided into the low-frequency group (≤3 times, 351 cases), medium-frequency group (3-7 times, 172 cases) and high-frequency group (≥8 times, 87 cases). Multiple stepwise regression was used to analyse the correlation between hypoglycaemia and cognitive function.  Results  (1) The cognitive function score of the non-hypoglycaemia group [(26.13±1.28) points] was significantly better than that of the mild [(24.92±1.12) points] and severe hypoglycaemia groups [(24.73±1.25) points, F=78.601, P < 0.01]. (2) Statistically significant differences were observed in the incidence of cognitive dysfunction amongst groups with different frequency of hypoglycaemia (P < 0.05). The incidence of cognitive dysfunction was the highest in the high-frequency group (68.97%) and the lowest in the low-frequency group (38.75%). Significant differences were observed in the incidence of cognitive dysfunction amongst groups with different degrees of hypoglycaemia (P < 0.05). The incidence of cognitive dysfunction was the highest in the severe hypoglycaemia group (75.00%) and lowest in the non-hypoglycaemia group (31.07%). (3) The occurrence, frequency and degree of hypoglycaemia were important factors affecting patients' cognitive dysfunction.  Conclusion  Hypoglycaemia is a risk factor for cognitive impairment in diabetic patients. The frequency and degree of hypoglycaemia can affect the cognitive level of elderly diabetic patients.

     

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