Volume 19 Issue 10
Oct.  2021
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(10): 1789-1792
ZHANG Ting, HAN Ai-zhi, LONG Zhang-biao, GE Jian, YANG Ming-zhen. Clinical analysis and nursing measures of cutaneous GVHD after allogeneic haematopoietic stem cell transplantation in 152 patients[J]. Chinese Journal of General Practice, 2021, 19(10): 1789-1792. doi: 10.16766/j.cnki.issn.1674-4152.002168
Citation: ZHANG Ting, HAN Ai-zhi, LONG Zhang-biao, GE Jian, YANG Ming-zhen. Clinical analysis and nursing measures of cutaneous GVHD after allogeneic haematopoietic stem cell transplantation in 152 patients[J]. Chinese Journal of General Practice, 2021, 19(10): 1789-1792. doi: 10.16766/j.cnki.issn.1674-4152.002168
shu

Clinical analysis and nursing measures of cutaneous GVHD after allogeneic haematopoietic stem cell transplantation in 152 patients

doi: 10.16766/j.cnki.issn.1674-4152.002168

  • Department of Hematology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China

Funds:

 81900118

 1708085MH224

 201904a07020057

  • Received Date: 2021-02-21
    Available Online: 2022-02-15
    Abstract
  •   Objective  To explore the clinical characteristics and risk factors associated with cutaneous graft-versus-host disease (GVHD) after allogeneic haematopoietic stem cell transplantation (allo-HSCT) and put forward prevention and treatment nursing countermeasures for cutaneous GVHD.  Methods  The clinical data of 152 patients who received successful allo-HSCT from June 2008 to December 2019 and were followed up for more than six months were retrospectively analysed. Data regarding patient transplantation, including the occurrence of cutaneous GVHD, patients' conditions and disease-related information, were recorded. Follow-up to June 22, 2020, using inpatient records, outpatient, telephone and WeChat platform follow-up. Patients with cutaneous GVHD were given individualised comprehensive nursing interventions according to their grade or severity.  Results  A total of 94 cases of cutaneous GVHD were diagnosed in 152 allo-HSCT patients, with an occurrence rate of 61.84%. Amongst them, 36 cases (23.68%) were acute, and 69 cases (45.39%) were chronic. Multi-factor analysis showed that high-risk patients, blood type mismatch, human leucocyte antigen mismatch and the occurrence of systemic chronic GVHD were important risk factors for cutaneous GVHD. After the treatment and care of 94 cases of cutaneous GVHD, 70 cases of cutaneous injury improved, and 24 cases died. The fatality rate was 25.53%.  Conclusion  Cutaneous GVHD seriously affects patients' daily life and prognostics. Thus, donors with compatible blood type and HLA type should be preferred, and effective nursing intervention programs should be performed to reduce the degree of cutaneous injury of patients.

     

    • FullText(HTML)
  • loading
    • References(18)
  • [1]
    中国异基因造血干细胞移植治疗血液系统疾病专家共识(Ⅲ)——急性移植物抗宿主病(2020年版)[J]. 中华血液学杂志, 2020, 41(7): 529-536.
    [2]
    PASSWEG J R, BALDOMERO H, BADER P, et al. Use of haploidentical stem cell transplantation continues to increase: The 2015 European Society for Blood and Marrow Transplant activity survey report[J]. Bone Marrow Transplant, 2017, 52(6): 811-817. doi: 10.1038/bmt.2017.34
    [3]
    SCHOEMANS H M, LEE S J, FERRARA J L, et al. EBMT-NIH-CIBMTR task force position statement on standardized terminology & guidance for graft-versus-host disease assessment[J]. Bone Marrow Transplant, 2018, 53(11): 1401-1415. doi: 10.1038/s41409-018-0204-7
    [4]
    STRONG R K, OLIVEIRA-RIBEIRO C, DE ABREU F S, et al. Cutaneous Graft-Versus-Host disease: Diagnosis and treatment[J]. Am J Clin Dermatol, 2018, 19(1): 33-50. doi: 10.1007/s40257-017-0306-9
    [5]
    PENACK O, MARCHETTI M, RUUTU T, et al. Prophylaxis and management of graft versus host disease after stem-cell transplantation for haematological malignancies: Updated consensus recommendations of the European Society for Blood and Marrow Transplantation[J]. Lancet Haematol, 2020, 7(2): e157-e167. doi: 10.1016/S2352-3026(19)30256-X
    [6]
    DIGNAN F L, CLARK A, AMROLIA P, et al. Diagnosis and management of acute graft-versus-host disease[J]. Br J Haematol, 2012, 158(1): 30-45. doi: 10.1111/j.1365-2141.2012.09129.x
    [7]
    沈悌, 赵永强. 血液病诊断及疗效标准[M]. 4版. 北京: 科学出版社, 2018.
    [8]
    JAGASIA M H, GREINIX H T, ARORA M, et al. National institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: Ⅵ. the 2014 diagnois and staging working group report[J]. Biol Blood Marrow Transplant, 2015, 21(3): 389-401. doi: 10.1016/j.bbmt.2014.12.001
    [9]
    王佳丽, 韩明哲. 异基因造血干细胞移植后植入功能不良发生机制研究进展[J]. 中华血液学杂志, 2019, 40(9): 792-795.
    [10]
    SHI C R, HUANG J T, NAMBUDIRI V E. Pediatric cutaneous graft versus host disease: A review[J]. Curr Pediatr Rev, 2017, 13(2): 100-110. http://www.onacademic.com/detail/journal_1000040278208610_02d2.html
    [11]
    胡宇晴, 张建中. 同时具有硬皮病样和皮肤异色病样皮损的慢性移植物抗宿主病[J]. 临床皮肤科杂志, 2020, 49(2): 95-97. https://www.cnki.com.cn/Article/CJFDTOTAL-LCPF202002010.htm
    [12]
    SANTOS E P, BENNETT C L, CHAKRAVERTY R. Unraveling the mechanisms of cutaneous Graft-Versus-Host disease[J]. Front Immunol, 2018, 9: 963. doi: 10.3389/fimmu.2018.00963
    [13]
    田伟, 郑雅男, 冯昌银, 等. 急性皮肤型移植物抗宿主病8例临床分析并文献复习[J]. 临床皮肤科杂志, 2015, 44(11): 682-684. https://www.cnki.com.cn/Article/CJFDTOTAL-LCPF201511003.htm
    [14]
    杨欢, 李志涛, 林韧, 等. 造血干细胞移植后硬皮病样慢性移植物抗宿主病的临床表现[J]. 南方医科大学学报, 2016, 36(6): 807-813. doi: 10.3969/j.issn.1673-4254.2016.06.13
    [15]
    NANDA A, HUSAIN M A A, AL-HERZ W, et al. Chronic cutaneous graft-versus-host disease in children: A report of 14 patients from a tertiary care pediatric dermatology clinic[J]. Pediatr Dermatol, 2018, 35(3): 343-353. doi: 10.1111/pde.13432
    [16]
    常英军. 我如何选择异基因造血干细胞移植供者[J]. 中华血液学杂志, 2016, 37(8): 643-649. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYY200732003.htm
    [17]
    李蒙娜, 闫言, 王宝玺. 紫草素促进皮肤伤口愈合机制研究进展[J]. 中医药学报, 2018, 46(2): 124-128. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXB201802032.htm
    [18]
    余新翠. 运用微信平台延伸护理服务对类风湿关节炎患者的影响[J]. 中华全科医学, 2017, 15(8): 1444-1446. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201708051.htm
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (187) PDF downloads(6) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return