Volume 19 Issue 11
Nov.  2021
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(11): 1819-1822
LU Bing, LIU Ye, CHEN Ji-hai, GU Liu-bao, FAN Yao, OUYANG Xiao-jun. Correlation between homocysteine and sarcopenia in elderly inpatients[J]. Chinese Journal of General Practice, 2021, 19(11): 1819-1822. doi: 10.16766/j.cnki.issn.1674-4152.002175
Citation: LU Bing, LIU Ye, CHEN Ji-hai, GU Liu-bao, FAN Yao, OUYANG Xiao-jun. Correlation between homocysteine and sarcopenia in elderly inpatients[J]. Chinese Journal of General Practice, 2021, 19(11): 1819-1822. doi: 10.16766/j.cnki.issn.1674-4152.002175
shu

Correlation between homocysteine and sarcopenia in elderly inpatients

doi: 10.16766/j.cnki.issn.1674-4152.002175
  • 1.

    Department of Geriatrics, Geriatric Hospital of Nanjing MedicalUniversity, Nanjing, Jiangsu 210024, China

Funds:

 BJ16025

 H2019038

 NMUB2020186

  • Received Date: 2020-10-22
    Abstract
  •   Objective  To explore the association of serum homocysteine (Hcy) levels with sarcopenia and cognitive function in elderly inpatients.   Methods  A total of 346 elderly patients hospitalized in The Affiliated Geriatric Hospital of Nanjing Medical University from June 2017 to March 2020 were selected, including 122 cases (35.3%) with sarcopenia and 224 cases (64.7%) without sarcopenia. Walking speed, grip strength and limb skeletal muscle index (ASMI) were used to diagnose sarcopenia, and MMSE was used to assess cognitive function. The differences in Hcy level and cognitive function between the sarcopenia group and the non-sarcopenia group were compared, the relationship between Hcy level and the severity and cognitive function of sarcopenia was analyzed, and the influencing factors related to sarcopenia were analyzed by multiple factors.   Results  (1) Compared with the non-sarcopenia group, the sarcopenia group was older and had lower body mass index (BMI), serum albumin level, MMSE score and education level (all P < 0.001) and higher Hcy level (P=0.011). (2) Pearson correlation analysis showed that high Hcy level was negatively correlated with low gait speed, low ASMI and low MMSE score (all P < 0.05). (3) Multivariate logistic regression analysis revealed that age, high BMI and high education level were related to sarcopenia in total subjects. High education level and high BMI in males and age, high Hcy level, high BMI and high education level in females were associated with the presence of sarcopenia.   Conclusions  The higher Hcy level in elderly patients with sarcopenia, the more severe the decline of ASMI, gait speed and cognitive function. High Hcy level is a risk factor for sarcopenia in elderly women. High education level and high BMI are protective factors for sarcopenia. Serum Hcy level may be used as a monitoring index for sarcopenia, which has a certain clinical significance in disease evaluation and prognosis prediction.

     

    • FullText(HTML)
  • loading
    • References(22)
  • [1]
    WANG L, NIU H, ZHANG J. Homocysteine induces mitochondrial dysfunction and oxidative stress in myocardial ischemia/reperfusion injury through stimulating ROS production and the ERK1/2 signaling pathway[J]. Exp Ther Med, 2020, 20(2): 938-944. doi: 10.3892/etm.2020.8735
    [2]
    BONETTI F, BROMBO G, ZULIANI G. The relationship between hyperhomocysteinemia and neurodegeneration[J]. Neurodegener Dis Manag, 2016, 6(2): 133-145. doi: 10.2217/nmt-2015-0008
    [3]
    CHEN S, DONG Z, CHENG M, et al. Homocysteine exaggerates microglia activation and neuroinflammation through microglia localized STAT3 overactivation following ischemic stroke[J]. J Neuroinflammation, 2017, 14(1): 187. doi: 10.1186/s12974-017-0963-x
    [4]
    KOZAKOVA M, MORIZZO C, PENNO G, et al. Plasma Homocysteine and cardiovascular organ damage in a population with a high prevalence of risk factors[J]. J Clin Endocrinol Metab, 2020, 105(8): dgaa289. http://www.researchgate.net/publication/341657976_Plasma_Homocysteine_and_Cardiovascular_Organ_Damage_in_a_Population_with_a_High_Prevalence_of_Risk_Factors
    [5]
    XIE Y, FENG H, PENG S, et al. Association of plasma homocysteine, vitamin B12 and folate levels with cognitive function in Parkinson's disease: A meta-analysis[J]. Neurosci Lett, 2017, 636(1): 190-195. http://www.sciencedirect.com/science/article/pii/S0304394016308461
    [6]
    CRUZ-JENTOFT A J, BAHAT G, BAUER J, et al. Sarcopenia: Revised European consensus on definition and diagnosis[J]. Age Ageing, 2019, 48(1): 16-31. doi: 10.1093/ageing/afy169
    [7]
    VEERANKI S, LOMINADZE D, TYAGI S C. Hyperhomocysteinemia inhibits satellite cell regenerative capacity through p38 alpha/beta MAPK signaling[J]. Am J Physiol Heart Circ Physiol, 2015, 309(2): H325-334. doi: 10.1152/ajpheart.00099.2015
    [8]
    CHEN L K, WOO J, ASSANTACHAI P, et al. Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment[J]. J Am Med Dir Assoc, 2020, 21(3): 300-307. e2. doi: 10.1016/j.jamda.2019.12.012
    [9]
    LI H, JIA J, YANG Z. Mini-Mental state examination in elderly Chinese: A population-based normative study[J]. J Alzheimers Dis, 2016, 53(2): 487-496. doi: 10.3233/JAD-160119
    [10]
    CAMPOS F, ABRIGO J, AGUIRRE F, et al. Sarcopenia in a mice model of chronic liver disease: Role of the ubiquitin-proteasome system and oxidative stress[J]. Pflugers Arch, 2018, 470(10): 1503-1519. doi: 10.1007/s00424-018-2167-3
    [11]
    张宁, 朱文玲, 刘晓红, 等. 住院老年冠心病患者衰弱与肌肉功能评价的横断面分析[J]. 中华内科杂志, 2019, 58(4): 265-269.
    [12]
    KIM J, KIM H, ROH H, et al. Causes of hyperhomocysteinemia and its pathological significance[J]. Arch Pharm Res, 2018, 41(4): 372-383. doi: 10.1007/s12272-018-1016-4
    [13]
    INGENBLEEK Y. Lean body mass harbors sensing mechanisms that allow safeguarding of methionine homeostasis[J]. Nutrients, 2017, 9(9): 1035. doi: 10.3390/nu9091035
    [14]
    陈茉莉, 夏莉, 赵伟, 等. 血清同型半胱氨酸与原发性肝癌的相关性研究[J]. 中华全科医学, 2020, 18(9): 1443-1445, 1465. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY202009004.htm
    [15]
    VIDONI M L, PETTEE GABRIEL K, LUO S T, et al. Relationship between homocysteine and muscle strength decline: The baltimore longitudinal study of aging[J]. J Gerontol A Biol Sci Med Sci, 2018, 73(4): 546-551. doi: 10.1093/gerona/glx161
    [16]
    DEGENS H, GAYAN-RAMIREZ G, VAN HEES H W. Smoking-induced skeletal muscle dysfunction: From evidence to mechanisms[J]. Am J Respir Crit Care Med, 2015, 191(6): 620-625. doi: 10.1164/rccm.201410-1830PP
    [17]
    LEE W J, PENG L N, LOH C H, et al. Sex-different associations between serum homocysteine, high-sensitivity C-reactive protein and sarcopenia: Results from I-Lan Longitudinal Aging Study[J]. Exp Gerontol, 2020, 132(4): 110832. http://med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_PM31772093
    [18]
    PENG T C, CHEN W L, WU L W, et al. Sarcopenia and cognitive impairment: A systematic review and meta-analysis[J]. Clin Nutr, 2020, 39(9): 2695-2701. doi: 10.1016/j.clnu.2019.12.014
    [19]
    CHOU M Y, NISHITA Y, NAKAGAWA T, et al. Role of gait speed and grip strength in predicting 10-year cognitive decline among community-dwelling older people[J]. BMC Geriatr, 2019, 19(1): 186. doi: 10.1186/s12877-019-1199-7
    [20]
    SMITH A D, REFSUM H, BOTTIGLIERI T, et al. Homocysteine and dementia: An international consensus statement[J]. J Alzheimers Dis, 2018, 62(2): 561-570. doi: 10.3233/JAD-171042
    [21]
    陆冰, 潘晓东, 周林赟, 等. 老年高血压患者同型半胱氨酸水平与脑白质病变分级及认知功能的相关性研究[J]. 中华老年医学杂志, 2019, 38(3): 251-254.
    [22]
    SINK K M, ESPELAND M A, CASTRO C M, et al. Effect of a 24-Month physical activity intervention vs health education on cognitive outcomes in sedentary older adults: The LIFE randomized trial[J]. JAMA, 2015, 314(8): 781-790. doi: 10.1001/jama.2015.9617
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (205) PDF downloads(9) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return