Volume 19 Issue 11
Nov.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(11): 1872-1874,1983
ZHANG Hui-juan, QIU Jian-li, YAN Yong-bin, SUN Xiao-xu, ZHAO Qian-yi. Observation on the curative effect of tanshinone combined with azithromycin in the treatment of children with mycoplasma pneumonia[J]. Chinese Journal of General Practice, 2021, 19(11): 1872-1874,1983. doi: 10.16766/j.cnki.issn.1674-4152.002189
Citation: ZHANG Hui-juan, QIU Jian-li, YAN Yong-bin, SUN Xiao-xu, ZHAO Qian-yi. Observation on the curative effect of tanshinone combined with azithromycin in the treatment of children with mycoplasma pneumonia[J]. Chinese Journal of General Practice, 2021, 19(11): 1872-1874,1983. doi: 10.16766/j.cnki.issn.1674-4152.002189
shu

Observation on the curative effect of tanshinone combined with azithromycin in the treatment of children with mycoplasma pneumonia

doi: 10.16766/j.cnki.issn.1674-4152.002189

  • Department of Pediatrics, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, 450000, China

Funds:

 82004419

  • Received Date: 2021-03-15
    Available Online: 2022-02-15
    Abstract
  •   Objective  To observe the efficacy of tanshinone in the treatment of children with mycoplasma pneumonia (MP) and its effect on the expression of serum IL-6, TNF-α, TGF-β1 and Smad3.  Methods  A total of 100 children with MP were selected from January 2018 to September 2020, and they were divided into observation group and control group according to the random number table method, with 50 cases in each group. Azithromycin was used in the control group, and azithromycin combined with tanshinone was used in the observation group. The total effective rate, the time of symptom disappearance, the expression of serum IL-6, TNF-α, TGF-β1 and Smad3, and adverse reactions were compared between the two groups.  Results  The total effective rate in the observation group was 92.00%, which was higher than 76.00% in the control group (P < 0.05). The disappearance time of cough, fever, rales and wheeze in the observation group were (5.37±0.94) d, (2.71±0.51) d, (4.73±0.84) d, (5.82±1.02) d, which were shorter than those in the control group [(6.89±0.88) d, (3.53±0.72) d, (6.23±0.91) d, (7.11±1.31) d, P < 0.05]. The serum levels of IL-6, TNF-α, TGF-β1, and expression of Smad3 after treatment in the observation group were (16.16±5.49) pg/mL, (7.18±1.71) pg/mL, (15.22±3.06) μg/L, 0.20 ± 0.06, which were lower than those in the control group [(25.41±6.0) pg/mL, (12.98±2.61) pg/mL, (27.27±5.28) μg/L, 0.26±0.07, all P < 0.05]. There was no significant difference in total incidence of adverse reactions (14.00% vs 10.00%) between the two groups (P>0.05).  Conclusion  Tanshinone can down-regulate the expression of Smad3 to reduce serum TGF-β1, IL-6, and TNF-α. It has satisfactory results in the treatment of children with MP and has high safety.

     

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