Volume 19 Issue 11
Nov.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(11): 1875-1879
YANG Ming, GU Fei, ZHU Yun, LIU Xiao-yan, GAO Ying. Comparative study of several Chinese patent medicines for strengthening spleen and digestion in the treatment of subacute eczema in children[J]. Chinese Journal of General Practice, 2021, 19(11): 1875-1879. doi: 10.16766/j.cnki.issn.1674-4152.002190
Citation: YANG Ming, GU Fei, ZHU Yun, LIU Xiao-yan, GAO Ying. Comparative study of several Chinese patent medicines for strengthening spleen and digestion in the treatment of subacute eczema in children[J]. Chinese Journal of General Practice, 2021, 19(11): 1875-1879. doi: 10.16766/j.cnki.issn.1674-4152.002190
shu

Comparative study of several Chinese patent medicines for strengthening spleen and digestion in the treatment of subacute eczema in children

doi: 10.16766/j.cnki.issn.1674-4152.002190

  • Department of Dermatology, Children's Hospital Capital Institute of Pediatrics, Beijing 100020, China

Funds:

 81703106

  • Received Date: 2021-03-11
    Available Online: 2022-02-15
    Abstract
  •   Objective  To observe and compare the clinical efficacy and safety of several Chinese patent medicines for strengthening spleen and digestion in the treatment of subacute eczema in children.  Methods  The clinical data of 186 cases of children with subacute eczema treated in the Children' s Hospital Capital Institute of Pediatrics from June 2018 to June 2019 were retrospectively analyzed. The children were divided into control group (48 cases, conventional Western medicine) and observation group (138 cases, combined with Chinese patent medicines for strengthening spleen and digestion on the basis of the treatment of the control group) according to the treatment plan. The observation group was divided into group A (42 cases), group B (57 cases) and group C (39 cases) according to the difference of Chinese patent medicine, and the medicines included Xiaoerfupi Granule, Xiaoerkang Granule and Shenquxiaoshi Oral Liquid. Then, the efficacy, recurrence, pruritus, quality of life and adverse reactions were compared.  Results  After one course of treatment, the total effective rates of observation groups A, B and C (83.33%, 85.96% and 79.49%, respectively) were higher than that of the control group (58.33%), and the difference between group B and the control group was significant (P < 0.008). After one course of treatment, the pruritus and quality of life scores of observation groups A, B and C [the pruritus score was (0.64±0.53) points, (0.49±0.37) points and (0.56±0.48) points, respectively; CDLQI scores were (5.24±1.93) points, (5.04±1.01) points and (5.59±2.13) points, respectively] were significantly improved compared with the control group [pruritus score and CDLQI score were (1.41±0.72) points and (8.70±2.91) points, respectively, all P < 0.05]. However, no significant difference was observed amongst the three observation groups (all P>0.05). The recurrence rates of eczema at 3 months in the three observation groups were obviously lower than that in the control group (P < 0.008), and this rate at 3 months was significantly lower in group B (19.30%) than in group A (46.34%, P < 0.008). Only minor adverse reactions occurred in each group during treatment, and no significant difference was observed in the incidence of adverse reactions (P>0.05).  Conclusion  In the treatment of subacute eczema in children with the Chinese patent medicines for strengthening spleen and digestion combined with western medicine for routine treatment, Xiaoerkang Keli have more advantages in improving curative effect and reducing the recurrence rate, and deserve further attention.

     

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