Volume 19 Issue 11
Nov.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(11): 1880-1883
PENG Zhao-qing, LI Yu-zhi, LIU Hong-li, LIU Meng-jun, DENG Li-wen. Clinicopathological analysis of 165 cases of total hysterectomy with cervical HSIL[J]. Chinese Journal of General Practice, 2021, 19(11): 1880-1883. doi: 10.16766/j.cnki.issn.1674-4152.002191
Citation: PENG Zhao-qing, LI Yu-zhi, LIU Hong-li, LIU Meng-jun, DENG Li-wen. Clinicopathological analysis of 165 cases of total hysterectomy with cervical HSIL[J]. Chinese Journal of General Practice, 2021, 19(11): 1880-1883. doi: 10.16766/j.cnki.issn.1674-4152.002191
shu

Clinicopathological analysis of 165 cases of total hysterectomy with cervical HSIL

doi: 10.16766/j.cnki.issn.1674-4152.002191

  • Department of Obstetrics and Gynecology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0346

  • Received Date: 2021-03-25
    Available Online: 2022-02-15
    Abstract
  •   Objective  To investigate the related risk factors and pathological characteristics of pathologically upgraded invasive carcinoma after total hysterectomy in the initial treatment of cervical high-grade squamous intraepithelial lesion (HSIL).  Methods  Retrospective analysis was performed on 165 patients who received total hysterectomy as initial treatment for HSIL in the First Affiliated Hospital of Bengbu Medical College from January 2010 to January 2020. They were divided into premenopausal group (52 cases) and menopausal group (113 cases). According to pathology, they were divided into infiltrating group and non-infiltrating group. The related risk factors and pathological characteristics of pathological progression were studied.  Results  Among the 165 HSIL cases, 26 cases had invasive cancer, with a total incidence of (15.8%, 26/165). The pathological upgrading rate of the premenopausal group was 11.5% (6/52). The pathological upgrading rate of the menopausal group was 17.7% (20/113). Univariate analysis in premenopausal group: lesion number ≥ 3 points, lesion gland accumulation and abortion ≥ 2 times were the risk factors of pathological upgrading. Logistic regression analysis showed that lesion number ≥ 3 points and lesion gland accumulation were the independent risk factors of pathological upgrading. Univariate analysis in menopausal group: the number of lesions ≥ 3 points, gland accumulation and menopausal years ≥ 5 years were the risk factors of pathological upgrading. Logistic regression analysis showed that these three points were also the independent risk factors of pathological upgrading. Six cases of invasive cancer in premenopausal group, 4 cases of ⅠA1 stage, 2 cases of lymphatic vascular infiltration in ⅠA2 stage. Among the 20 patients in the menopausal group, 16 patients had stage ⅠA1, including 1 patient with lymphatic vascular infiltration and 4 patients with stage ⅠA2.  Conclusion  There is no significant difference in pathological upgrading between menopausal and premenopausal patients. For patients with HSIL, regardless of menopause or not, the number of lesions ≥ 3 and the number of lesion glands should be vigilant against the occurrence of invasive cancer. The pathological upgrading rate will increase in patients with menopausal years>5 years. The pathology of HSIL patients after total hysterectomy was all early invasive carcinoma.

     

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