Volume 19 Issue 11
Nov.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(11): 1925-1928,1955
JIANG Hai-yan, WANG Yin-xue, WANG Jian-yun, LIU Da-min, SUN Hui-yi, ZHANG Wen. Clinical study of Jiedu Huoxue Decoction enema combined with oral Chinese medicine in patients with ulcerative colitis[J]. Chinese Journal of General Practice, 2021, 19(11): 1925-1928,1955. doi: 10.16766/j.cnki.issn.1674-4152.002202
Citation: JIANG Hai-yan, WANG Yin-xue, WANG Jian-yun, LIU Da-min, SUN Hui-yi, ZHANG Wen. Clinical study of Jiedu Huoxue Decoction enema combined with oral Chinese medicine in patients with ulcerative colitis[J]. Chinese Journal of General Practice, 2021, 19(11): 1925-1928,1955. doi: 10.16766/j.cnki.issn.1674-4152.002202
shu

Clinical study of Jiedu Huoxue Decoction enema combined with oral Chinese medicine in patients with ulcerative colitis

doi: 10.16766/j.cnki.issn.1674-4152.002202
  • 1.

    Department of Gastroenterology, the 3rd Hospital Affiliated Beijing University of Chinese Medicine, Beijing 100029, China

Funds:

 81873214

 2019-JYB-JS-39

  • Received Date: 2020-11-03
    Available Online: 2022-02-15
    Abstract
  •   Objective  To evaluate the efficacy of Jiedu Huoxue Decoction enema combined with oral Chinese medicine in treating ulcerative colitis (UC) and explore the possible mechanism of action.  Methods  Total 80 patients with UC were selected from inpatients and outpatients in Dongzhimen Hospital of the Beijing University of Chinese Medicine and the Third Hospital affiliated Beijing University of Chinese Medicine from July 2016 to June 2018. According to the random number table method, 40 patients in the enema group were treated with Jiedu Huoxue Decoction enema combined with oral Chinese medicine, whereas 40 patients in the control group were treated with oral Chinese medicine only. The modified Mayo score was used to determine the clinical efficacy before and after treatment. The levels of inflammatory cytokine in the serum before and after treatment were determined. The expressions of vascular endothelial growth factor (VEGF) and anti-mucosal addressin cellular adhesion molecule-1 (Madcam-1) in the colon tissue before and after treatment were also observed. Effective telephone follow-up was conducted for 2 years.  Results  The modified Mayo scores of both groups decreased with time after treatment (P < 0.05). After 2 and 4 weeks of treatment, the improved Mayo scores of the enema group [(3.30±0.18) points and (4.30±0.27) points], were significantly lower than those of the control group [(4.85±0.45) points and (6.15±0.38) points, P < 0.05]. After 3 months of treatment, the serum levels of IL-8, TNF-α, VEGF and Madcam-1 in the two groups were significantly lower than those before treatment (P < 0.05). The serum levels of IL-8, TNF-α, VEGF and Madcam-1 in the enema group were significantly lower than those in the control group (P < 0.05). The expressions of VEGF and Madcam-1 in the colonic mucosa of the two groups were lower than before treatment (P < 0.05). The results of 2-year telephone follow-up showed that the recurrence rate of the enema group was significantly lower than that of the control group (P < 0.05).  Conclusion  Oral Chinese materia medica is effective in treating UC, whereas enema can relieve symptoms more quickly. It may reduce the release of inflammatory factors, thus reducing vascular inflammation and keeping patients in remission for a longer period.

     

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