Volume 19 Issue 12
Dec.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(12): 1999-2002, 2092
WANG Wen-juan, HUANG Li-nian, XU Qi-xia, XIA Xue-mei, RUI Yan, PANG Ying-ying, PANG Qing. Clinical study on the relationship between the changes of fractional exhaled nitric oxide and the severity of OSAHS before and after sleep[J]. Chinese Journal of General Practice, 2021, 19(12): 1999-2002, 2092. doi: 10.16766/j.cnki.issn.1674-4152.002220
Citation: WANG Wen-juan, HUANG Li-nian, XU Qi-xia, XIA Xue-mei, RUI Yan, PANG Ying-ying, PANG Qing. Clinical study on the relationship between the changes of fractional exhaled nitric oxide and the severity of OSAHS before and after sleep[J]. Chinese Journal of General Practice, 2021, 19(12): 1999-2002, 2092. doi: 10.16766/j.cnki.issn.1674-4152.002220
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Clinical study on the relationship between the changes of fractional exhaled nitric oxide and the severity of OSAHS before and after sleep

doi: 10.16766/j.cnki.issn.1674-4152.002220

  • Pulmonary Function Room, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233000, China

Funds:

 81600452

 BYKY18602D

  • Received Date: 2021-07-21
    Available Online: 2022-03-02
    Abstract
  •   Objective  To explore the clinical value of changes of fractional exhaled nitric oxide (eNO) levels before and after sleep in evaluating the disease severity of patients with obstructive sleep apnea hypopnea syndrome (OSAHS).  Methods  A total of 48 patients diagnosed with OSAHS from November 2018 to October 2019 in the First Affiliated Hospital of Bengbu Medical College were selected as OSA group, 62 healthy people were recruited as the control group. The pre-sleep and post-sleep levels of eNO [including nasal exhaled NO (FnNO), upper airway exhaled NO (FeNO) and alveolar exhaled NO (CaNO)] were compared between the two groups. The correlation between the changes of eNO and apnea hypopnea index (AHI) in OSA group was analyzed.  Results  The pre-sleep level of FnNO [(468.78±117.19) μg/L] and the post-sleep level of FnNO [(479.21±130.57) μg/L] in the OSA group were higher than that in the control group[(371.52±130.21) μg/L, (379.10±129.65) μg/L, all P < 0.05]. The pre-sleep level of FeNO [(23.10±15.19) μg/L] and the post-sleep level of FeNO [(24.92±14.94) μg/L] in the OSA group were higher than that in the control group[(17.71±7.01) μg/L, (18.03±6.63) μg/L, all P < 0.05]. The pre-sleep level of CaNO in OSA group was slightly lower than that in the control group, the difference was not statistically significant. The post-sleep level of CaNO [(2.88±1.41) μg/L] in the OSA group was lower than that in the control group [(4.07±1.86) μg/L, P < 0.05]. Compared with pre-sleep, there were no significant differences in post-sleep levels of FeNO and FnNO in both groups, while the post-sleep level of CaNO [(2.88±1.41) μg/L] in the OSA group was significantly lower than that in pre-sleep [(3.86±1.40) μg/L].Spearman correlation analysis showed that there was a significant correlation between the changes of CaNO (△CaNO) and AHI (r=0.384, P=0.008). After stratification according to AHI, the level of CaNO significantly decreased in patients with severe OSAHS after sleep.  Conclusion  Compared with pre-sleep, the post-sleep level of CaNO is slightly decreased in patients with mild and moderate OSAHS, but significantly decreased in severe patients, and the change of CaNO is significantly correlated with AHI, suggesting that CaNO can evaluate the severity of OSAHS.

     

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