Volume 19 Issue 12
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QIN Su-hui, DUN Shi-juan. Analysis of risk factors for the pathogenesis and prognosis of patients with sepsis-associated coagulopathy[J]. Chinese Journal of General Practice, 2021, 19(12): 2020-2023. doi: 10.16766/j.cnki.issn.1674-4152.002225
Citation: QIN Su-hui, DUN Shi-juan. Analysis of risk factors for the pathogenesis and prognosis of patients with sepsis-associated coagulopathy[J]. Chinese Journal of General Practice, 2021, 19(12): 2020-2023. doi: 10.16766/j.cnki.issn.1674-4152.002225
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Analysis of risk factors for the pathogenesis and prognosis of patients with sepsis-associated coagulopathy

doi: 10.16766/j.cnki.issn.1674-4152.002225

  • Department of Critical Care Medicine, the First Affiliated Hospital of Bengbu College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0351

 KJ2018A0244

  • Received Date: 2021-09-27
    Available Online: 2022-03-02
    Abstract
  •   Objective  To analyse the onset of sepsis-associated coagulopathy (SAC) and the risk factors affecting prognosis, provide ideas for preventing the occurrence of sepsis coagulopathy and improve prognosis.  Methods  A total of 57 patients with sepsis, who were admitted to the Department of Critical Care Medicine of the First Affiliated Hospital of Bengbu Medical College from January 2020 to June 2021, were included. On the basis of the diagnostic criteria for sepsis coagulopathy, the patients were divided into the control group (diagnosed sepsis; the coagulation function is normal, 36 cases), the observation group (21 cases meet the diagnosis of coagulation dysfunction in sepsis), the death group (11 cases) and the survival group (46 cases). The general information of the research subjects, serum procalcitonin (PCT), activated partial thromboplastin time (APTT) and fibrinogen (FIB) was collected, and the pathogenesis and prognosis of sepsis coagulopathy was analysed by comparing the two groups of clinical data risk factors.  Results  No statistically significant difference in age and gender was found between the observation group and control group (P>0.05). The levels of serum PCT and APTT in the observation group were significantly higher than those in the control group [33.46(23.11, 63.25) ng/mL vs.6.85(2.35, 8.77) ng/mL; 37.40(32.15, 45.15) s vs. 29.50(25.75, 33.50) s]. In addition, the FIB level decreased significantly [(2.90±0.95) g/L vs. (5.01±1.08) g/L], and the difference was statistically significant (all P < 0.05). There was no significant difference in age、gender and APTT between the death group and the survival group (all P>0.05).The serum PCT levels in death group was significantly higher than those in the survival group [44.73(7.48, 63.90) ng/mL vs. 7.78(3.56, 14.86) ng/mL], and the FIB level decreased significantly [(3.28±1.45) g/L vs. (4.46±1.37) g/L], and the difference was statistically significant (all P < 0.05). Factor logistic regression analysis indicated that the increase in PCT (OR=1.275, 95% CI: 1.049-1.550) and the decrease in FIB (OR=0.124, 95% CI: 0.023-0.676) were considered as risk factors for SAC, and the increase in PCT (OR=0.918, 95% CI: 0.859-0.981) was considered as a risk factor for the prognosis of SAC (all P < 0.05).  Conclusion  In clinical practice, when the serum PCT level increases and the FIB level decreases, SAC may occur. The continuous increase of the PCT level in patients diagnosed with SAC may indicate a poor prognosis.

     

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