Clinical effect of platelet lysate on lumbar interbody fusion in elderly patients with lumbar disc herniation

MA Guang-xi; ZHANG Jun; YANG Yi-yu; WANG Yu

doi:10.16766/j.cnki.issn.1674-4152.002234

Volume 19 Issue 12

Dec. 2021

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Article Navigation > Chinese Journal of General Practice > 2021 > 19(12): 2051-2054

MA Guang-xi, ZHANG Jun, YANG Yi-yu, WANG Yu. Clinical effect of platelet lysate on lumbar interbody fusion in elderly patients with lumbar disc herniation[J]. Chinese Journal of General Practice, 2021, 19(12): 2051-2054. doi: 10.16766/j.cnki.issn.1674-4152.002234

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MA Guang-xi, ZHANG Jun, YANG Yi-yu, WANG Yu. Clinical effect of platelet lysate on lumbar interbody fusion in elderly patients with lumbar disc herniation[J]. Chinese Journal of General Practice, 2021, 19(12): 2051-2054. doi: 10.16766/j.cnki.issn.1674-4152.002234

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Clinical effect of platelet lysate on lumbar interbody fusion in elderly patients with lumbar disc herniation

doi: 10.16766/j.cnki.issn.1674-4152.002234

MA Guang-xi^{1
,
,}
, ZHANG Jun¹
, YANG Yi-yu¹
, WANG Yu²

1.
Department of Spinal Surgery, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, Zhejiang 325000, China

Funds:

LY21H060007

Received Date: 2021-06-16
Available Online: 2022-03-02

Abstract

Abstract

Objective To evaluate the clinical efficacy of platelet lysate in the treatment of elderly patients with lumbar disc herniation after vertebral fusion. Methods A total of 140 elderly patients with minimally invasive transforaminal lumbar interbody fusion who were in our hospital from April 2018 to April 2020 were randomly divided into study group and control group, with 70 cases in each group. Both groups were treated with minimally invasive transforaminal lumbar interbody fusion, and the study group was treated with platelet lysate injection. The operation indexes were recorded, and the pain reaction and lumbar function of the two groups were evaluated before and after operation. The differences in lumbar imaging indexes were compared 12 months after operation, and the postoperative complications were observed. Results The operation time of the study group was (182.41±17.28) min, which was significantly longer than that of the control group (167.86±15.49) min, t=5.219, P < 0.001, but no significant differences in blood loss and hospital stay were found between the control group and control group [(218.64±19.53) mL vs. (221.57±19.06) mL and (6.59±0.71) days vs. (6.41±0.69) days; t=0.896, 1.514; P=0.372, 0.132]. The visual analogue scale (VAS) score and ODI score at 3, 6, 9 and 12 months after operation in the study group were significantly lower than those in the control group (all P < 0.001). In addition, no significant difference in the fusion rate was found between the two groups 12 months after operation (98.57% vs. 94.28%, χ²=0.830, P=0.362), whereas the number of fusion layers (4.68±0.52) and the height of lumbar intervertebral space [(11.62±1.12) mm] in the study group were significantly higher than those in the control group [(2.91±0.34) and (10.53±1.04) mm; t=23.873, 5.891, all P < 0.001)]. No complications in the two groups within 12 months after operation. Conclusion Platelet lysate injection into lumbar intervertebral space can relieve the pain reaction after lumbar fusion in elderly patients with lumbar disc herniation and improve the recovery level of lumbar function, the healing degree and stability of lumbar intervertebral tissue. This method has high safety.
- Platelet lysate,
- Lumbar disc herniation,
- Vertebral fusion,
- Pain response,
- Lumbar function,
- Degree of healing,
- Clinical effect

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Clinical effect of platelet lysate on lumbar interbody fusion in elderly patients with lumbar disc herniation

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