Volume 19 Issue 12
Dec.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(12): 2110-2114
PAN Quan, CHEN Li-ping, LEI Hou-xing, WANG Hua-qiang, LI Rui. Effect of She Medicine Huoxue Xiaoji Recipe on clinical efficacy and endoplasmic reticulum stress in patients with H-type hypertension complicated left ventricular hypertrophy[J]. Chinese Journal of General Practice, 2021, 19(12): 2110-2114. doi: 10.16766/j.cnki.issn.1674-4152.002249
Citation: PAN Quan, CHEN Li-ping, LEI Hou-xing, WANG Hua-qiang, LI Rui. Effect of She Medicine Huoxue Xiaoji Recipe on clinical efficacy and endoplasmic reticulum stress in patients with H-type hypertension complicated left ventricular hypertrophy[J]. Chinese Journal of General Practice, 2021, 19(12): 2110-2114. doi: 10.16766/j.cnki.issn.1674-4152.002249
shu

Effect of She Medicine Huoxue Xiaoji Recipe on clinical efficacy and endoplasmic reticulum stress in patients with H-type hypertension complicated left ventricular hypertrophy

doi: 10.16766/j.cnki.issn.1674-4152.002249
  • 1.

    Department of Cardiology, Lishui City Hospital of Traditional Chinese Medicine, Lishui, Zhejiang 323000, China

Funds:

 国中医药人教函〔2019〕128号

 LY20B280003

 2016ZA208

 2017ZDYF04

 2018cxtd06

  • Received Date: 2020-04-01
    Available Online: 2022-03-02
    Abstract
  •   Objective  To observe the effect of Sheyi Huoxue Xiaoji Recipe on clinical efficacy and endoplasmic reticulum stress-related markers in patients with H-type hypertension complicated left ventricular hypertrophy and blood stasis syndrome, and explore its mechanism of action.  Methods  A total of 80 patients with H-type hypertension complicated left ventricular hypertrophy and blood stasis syndrome in Lishui City Hospital of Traditional Chinese Medicine from April 2018 to May 2019 were selected and randomly divided into the control group and observation group according to the number table method (each with 40 cases). The control group was treated with Western medicine, whilst the observation group was treated with Western medicine plus Sheyi Huoxue Xiaoji Recipe. The changes of antihypertensive efficacy, TCM syndrome scores, blood pressure levels, homocysteine (Hcy), left ventricular hypertrophy indicators and endoplasmic reticulum stress-related markers were compared in both groups, and adverse reactions were recorded.  Results  The total effective rate of lowering blood pressure in the observation group was 90.0%, which was higher than 72.5% in the control group (χ2=4.021, P=0.045). After treatment, the TCM syndrome score, blood pressure level, Hcy, left ventricular end-diastolic diameter and left ventricular mass index in the observation group were lower than those in the control group (all P < 0.05). After treatment, the serum glucose-regulated protein 78 [(6.25±1.83) ng/mL], protein kinase R-like ER kinase [(15.74±1.75) ng/mL] and C/EBP homologous protein [(8.52±0.65) ng/mL] were lower in the observation group than in the control group [(7.35±1.07) ng/mL, (16.85±1.82) ng/mL, (9.45±0.58) ng/mL, t=3.282, 2.780, 6.751, all P < 0.05]. No adverse reactions were observed in both groups.  Conclusion  The Sheyi Huoxue Xiaoji Recipe has a significant clinical effect in treating patients with H-type hypertension complicated left ventricular hypertrophy and blood stasis syndrome, which may be related to the effective regulation of endoplasmic reticulum stress.

     

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