Volume 19 Issue 12
Dec.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(12): 2119-2123
XU Dao-fen, SUN Yun, HU Xin-xin, GAO Chu-chu, ZHENG Hui-jun. Clinical observation of Bu Bao Decoction in improving infertility with luteal insufficiency caused by kidney yang deficiency type[J]. Chinese Journal of General Practice, 2021, 19(12): 2119-2123. doi: 10.16766/j.cnki.issn.1674-4152.002251
Citation: XU Dao-fen, SUN Yun, HU Xin-xin, GAO Chu-chu, ZHENG Hui-jun. Clinical observation of Bu Bao Decoction in improving infertility with luteal insufficiency caused by kidney yang deficiency type[J]. Chinese Journal of General Practice, 2021, 19(12): 2119-2123. doi: 10.16766/j.cnki.issn.1674-4152.002251
shu

Clinical observation of Bu Bao Decoction in improving infertility with luteal insufficiency caused by kidney yang deficiency type

doi: 10.16766/j.cnki.issn.1674-4152.002251

  • Department of Gynecology, Wenzhou Traditional Chinese Medicine Hospital, Wenzhou, Zhejiang 325000, China

Funds:

 2017ZQ025

 Y20190718

 ZS2017019

  • Received Date: 2020-05-12
    Available Online: 2022-03-02
    Abstract
  •   Objective  To investigate the clinical efficacy of Bu Bao Decoction in improving infertility with luteal insufficiency caused by kidney yang deficiency type and its effect on the endometrial haemodynamics, and analyse the safety during medication.  Methods  Eighty infertility patients with luteal insufficiency who were treated in Wenzhou Traditional Chinese Medicine Gynecology Clinic from January 2018 to March 2019 were selected and randomly divided into the observation group (40 cases) and control group (40 cases). The observation group was given Bu Bao Decoction, While the control group was given dydrogesterone tablets. The patients in both groups were treated continuously for three menstrual cycles. The clinical efficacy of the two groups, the improvement of kidney yang deficiency symptoms and the serum estradiol (E2) and progesterone (P) levels in the metaphase luteum were observed. Endometrial thickness, uterine artery blood flow resistance index (RI) and pulsatility index (PI) of patients were detected by ultrasound before and after treatment. Six-month follow-up was used to record the clinical pregnancy and adverse reactions in the two groups.  Results  The clinical effectiveness of the observation group was significantly higher than that of the control group [(35/40, 87.50%) vs. (27/40, 67.50%)], and the difference was statistically significant (Z=4.588, P=0.032). After treatment, the score of TCM kidney yang deficiency syndrome in the observation group was lower than that of the control group, and the serum E2 and P levels in the metaphase luteum were higher than those in the control group, the difference was statistically significant (t=9.046, 4.507, 5.143, all P < 0.05). The endometrial thickness of the observation group after treatment was higher than that of the control group, while RI and PI were lower than the control group, the difference was statistically significant (t=5.228, 4.005, 2.923, all P < 0.05). After follow-up for 6 months, the clinical pregnancy rate of the observation group was higher than that of the control group, and the difference was statistically significant (χ2=4.267, P=0.039). No statistically significant difference in the occurrence of adverse reactions was found between the two groups during treatment (P=0.999).  Conclusion  Bu Bao Decoction has a significant effect on treating infertility patients with luteum insufficiency caused by kidney yang deficiency. Moreover, it can significantly improve the luteum index and increase the pregnancy rate.

     

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