Volume 20 Issue 1
Jan.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(1): 117-120
YIN Wen-hao, JIN Meng-zhu, DAI Qing. Curative effect of fire acupuncture combined with acupuncture in the treatment of lower leg plaque psoriasis[J]. Chinese Journal of General Practice, 2022, 20(1): 117-120. doi: 10.16766/j.cnki.issn.1674-4152.002291
Citation: YIN Wen-hao, JIN Meng-zhu, DAI Qing. Curative effect of fire acupuncture combined with acupuncture in the treatment of lower leg plaque psoriasis[J]. Chinese Journal of General Practice, 2022, 20(1): 117-120. doi: 10.16766/j.cnki.issn.1674-4152.002291
shu

Curative effect of fire acupuncture combined with acupuncture in the treatment of lower leg plaque psoriasis

doi: 10.16766/j.cnki.issn.1674-4152.002291
  • 1.

    Department of Dermatology, the First Hospital of Jiaxing, Jiaxing, Zhejiang 314001, China

Funds:

 2015ZB114

 2019AD32242

  • Received Date: 2020-12-28
    Available Online: 2022-03-03
    Abstract
  •   Objective  To observe the clinical efficacy of fire acupuncture combined with acupuncture in the treatment of lower leg plaque psoriasis and the changes of endostatin (ES) and angiostatin (AS) levels before and after treatment.  Methods  A total of 105 patients with lower leg plaque psoriasis treated in the First Hospital of Jiaxing from May 2019 to April 2020 were selected and randomly divided into the conventional treatment group, fire acupuncture group and combined treatment group, with 35 cases in each group. The conventional treatment group was treated with external application of halcinonide cream combined with NB-UVB irradiation, the fire acupuncture group was treated with fire acupuncture combined with acupuncture, and the combined treatment group was treated with the above-mentioned treatments simultaneously. All the three groups were treated for 8 weeks. The clinical efficacy was evaluated by PASI score, and the serum levels of ES and AS were detected before treatment and 4 and 8 weeks after treatment.  Results  The PASI scores of the three groups decreased after 8 weeks of treatment (all P < 0.05). After treatment, no significant difference in PASI score was found between the conventional treatment group and fire acupuncture group (P>0.05), but the PASI score of the combined treatment group was lower than that of the conventional treatment group and the fire acupuncture group (all P < 0.05). In addition, no significant difference in the total effective rate was found between the conventional treatment group (54.29%) and fire acupuncture group (60.00%, P>0.05). The total effective rate of the combined treatment group (85.71%) was higher than that of the conventional treatment group and fire acupuncture group (all P < 0.05). The serum levels of ES and AS in the three groups increased with time (all P < 0.05). The serum ES level of the combined treatment group was higher than that of the conventional treatment group and fire acupuncture group after 4 weeks of treatment (all P < 0.05), and the serum AS level of the combined treatment group after 8 weeks of treatment was higher than that of the conventional treatment group and fire acupuncture group (all P < 0.05).  Conclusion  The curative effect of fire acupuncture combined with acupuncture in the treatment of lower leg plaque psoriasis is similar to that of conventional treatment. Combined treatment can improve the curative effect, and its mechanism may be related to the increase of ES and AS levels and the inhibition of angiogenesis.

     

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