Volume 20 Issue 2
Feb.  2022
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GUO Bin, CHEN Rui, WANG Sheng-ying, PENG Mei. Analysis of factors related to cervical lymph node metastasis in 208 patients with papillary thyroid carcinoma[J]. Chinese Journal of General Practice, 2022, 20(2): 195-198, 262. doi: 10.16766/j.cnki.issn.1674-4152.002310
Citation: GUO Bin, CHEN Rui, WANG Sheng-ying, PENG Mei. Analysis of factors related to cervical lymph node metastasis in 208 patients with papillary thyroid carcinoma[J]. Chinese Journal of General Practice, 2022, 20(2): 195-198, 262. doi: 10.16766/j.cnki.issn.1674-4152.002310

Analysis of factors related to cervical lymph node metastasis in 208 patients with papillary thyroid carcinoma

doi: 10.16766/j.cnki.issn.1674-4152.002310
Funds:

 201904A07020068

  • Received Date: 2021-04-16
    Available Online: 2022-03-04
  •   Objective  To explore the related factors of cervical lymph node metastasis in patients with papillary thyroid carcinoma (PTC), so as to provide the basis for clinical treatment decision-making and prognosis evaluation.  Methods  The ultrasonic, pathological and clinical data of 208 cases with PTC confirmed by pathology in the First Affiliated Hospital of the University of Science and Technology of China (Anhui Provincial Hospital) from June 2019 to December 2019 were collected. Univariate and multivariate logistic regression analysis was used to analyse the related factors of the cervical lymph node metastasis group and non-metastasis group.  Results  Amongst the 208 patients, 126 had cervical lymph node metastasis, and the rate of metastasis was 60.6%. A significant difference was observed in the cervical lymph node metastasis rate amongst different gender, age, tumour location, tumour length and diameter, abnormal lymph nodes, tumour aspect ratio >1, multifocal lesions, bilateral lesions, capsule invasion, nodal calcification and PTC patients with nodular goitre (all P < 0.05). The Results of multivariate logistic analysis showed that female (OR=0.386) was a protective factor for cervical lymph node metastasis in patients with PTC, and tumour located in the lower pole(OR=3.057), abnormal lymph nodes in ultrasound (OR=6.277) and multifocal lesions (OR=2.889) were independent risk factors for cervical lymph node metastasis in patients with PTC.  Conclusion  Cervical lymph node metastasis in PTC patients is closely related to many factors. Paying attention to and analysing these factors have important clinical significance for clinical staging, treatment decision-making and prognosis evaluation.

     

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  • [1]
    WANG J, YU F, SHANG Y, et al. Thyroid cancer: Incidence and mortality trends in China, 2005-2015[J]. Endocrine, 2020, 68(1): 163-173. doi: 10.1007/s12020-020-02207-6
    [2]
    张小鹏, 张俊青, 李晓铷, 等. 2011—2015年合肥市区恶性肿瘤发病和死亡分析[J]. 中国肿瘤, 2019, 28(12): 907-912. doi: 10.11735/j.issn.1004-0242.2019.12.A005
    [3]
    MAO L N, WANG P, LI Z Y, et al. Risk factor analysis for central nodal metastasis in papillary thyroid carcinoma[J]. Oncology letters, 2015, 9(1): 103-107. doi: 10.3892/ol.2014.2667
    [4]
    HAUGEN B R, ALEXANDER E K, BIBLE K C, et al. 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer[J]. Thyroid, 2016, 26(1): 1-133. doi: 10.1089/thy.2015.0020
    [5]
    AMIN M B, GREENE F L, EDGE S B, et al. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging[J]. CA Cancer J Clin, 2017, 67(2): 93-99. doi: 10.3322/caac.21388
    [6]
    GHARIB H, PAPINI E, GARBER J R, et al. American association of clinical endocrinologists, American college of endocrinology and associazione medici endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules-2016 update[J]. Endocr Pract, 2016, 22(5): 622-639.
    [7]
    BACK K, KIM J S, KIM J H, et al. Superior located papillary thyroid microcarcinoma is a risk factor for lateral lymph node metastasis[J]. Ann Surg Oncol, 2019, 26(12): 3992-4001. doi: 10.1245/s10434-019-07587-2
    [8]
    SHENG L, SHI J, HAN B, et al. Predicting factors for central or lateral lymph node metastasis in conventional papillary thyroid microcarcinoma[J]. Am J Surg, 2020, 220(2): 334-340. doi: 10.1016/j.amjsurg.2019.11.032
    [9]
    MA B, WANG Y, YANG S, et al. Predictive factors for central lymph node metastasis in patients with cN0 papillary thyroid carcinoma: A systematic review and meta-analysis[J]. Int J Surg, 2016, 28: 153-161. doi: 10.1016/j.ijsu.2016.02.093
    [10]
    王岩岩, 李莉, 彭德峰, 等. 甲状腺微小乳头状癌中央区淋巴结转移的相关因素分析[J]. 中华全科医学, 2018, 16(8): 1268-1270, 1282. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201808014.htm
    [11]
    GUI C Y, QIU S L, PENG Z H, et al. Clinical and pathologic predictors of central lymph node metastasis in papillary thyroid microcarcinoma: A retrospective cohort study[J]. J Endocrinol Invest, 2018, 41(4): 403-409. doi: 10.1007/s40618-017-0759-y
    [12]
    KIM S K, WOO J W, PARK I, et al. Computed tomography-detected central lymph node metastasis in ultrasonography node-negative papillary thyroid carcinoma: Is it really significant?[J]. Ann Surg Oncol, 2017, 24(2): 442-449. doi: 10.1245/s10434-016-5552-1
    [13]
    LIU Y, ZHOU H, YANG P, et al. Contrast-enhanced ultrasonography features of papillary thyroid carcinoma for predicting cervical lymph node metastasis[J]. Exp Ther Med, 2017, 14(5): 4321-4327. http://www.onacademic.com/detail/journal_1000040238785910_8a27.html
    [14]
    邓水平, 李泉水, 陈胜华, 等. 甲状腺微小乳头状癌的超声特征与颈部淋巴结转移相关因素分析[J]. 临床超声医学杂志, 2017, 19(6): 424-426. doi: 10.3969/j.issn.1008-6978.2017.06.025
    [15]
    LI R Q, YUAN G H, CHEN M, et al. Evaluation of diagnostic efficiency of ultrasound features on malignant thyroid nodules in Chinese patients[J]. Chin Med J (Engl), 2016, 129(15): 1784-1788. doi: 10.4103/0366-6999.186643
    [16]
    陈亮, 彭泉, 于华杰, 等. 甲状腺微小乳头状癌中央区淋巴结转移的危险因素分析[J]. 中国现代普通外科进展, 2019, 22(10): 818-820. https://www.cnki.com.cn/Article/CJFDTOTAL-PWJZ201910020.htm
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