Volume 20 Issue 2
Feb.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(2): 199-201, 281
PANG Ying-ying, LIU Hai-tao. Relationship between biomarkers and risk stratification and prognosis of acute pulmonary embolism[J]. Chinese Journal of General Practice, 2022, 20(2): 199-201, 281. doi: 10.16766/j.cnki.issn.1674-4152.002311
Citation: PANG Ying-ying, LIU Hai-tao. Relationship between biomarkers and risk stratification and prognosis of acute pulmonary embolism[J]. Chinese Journal of General Practice, 2022, 20(2): 199-201, 281. doi: 10.16766/j.cnki.issn.1674-4152.002311
shu

Relationship between biomarkers and risk stratification and prognosis of acute pulmonary embolism

doi: 10.16766/j.cnki.issn.1674-4152.002311

  • Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0395

 BYKY18100

  • Received Date: 2021-04-12
    Available Online: 2022-03-04
    Abstract
  •   Objective  To explore the application value of biomarkers in the risk stratification and prognosis of acute pulmonary embolism.  Methods  From January 2018 to November 2019, 90 patients with acute pulmonary embolism diagnosed by multi-slice spiral CT pulmonary angiography were selected as the observation group. In accordance with the 2014 European Heart Association (The European Society of Cardiology, ESC) guidelines, the patients were divided into a high-risk group (20 cases), a moderate-risk group (21 cases) and a low-risk group (49 cases). Another 50 healthy subjects of similar age in the same period were selected as the control group. The levels of B-type brain natriuretic peptide (BNP), troponin I (TnI) and ischaemic modified albumin (IMA) were measured by enzyme-linked immunosorbent assay, rapid quantitative detector and albumin cobalt binding assay, respectively.  Results  The serum levels of BNP, TnI and IMA in the observation group were significantly higher than those in the control group (P < 0.05). The median values of serum IMA, TnI and BNP in the high-risk group were 88.78 (85.63, 99.55) U/mL, 0.73 (0.19, 0.85) ng/mL and 2.63 (1.32, 5.48) ng/mL, respectively, and the levels in the high-risk group were significantly higher than those in the middle- and low-risk groups. In addition, the expression level in middle-risk group was significantly higher than that in the low-risk group. The median values of IMA, TnI and BNP in the dead group were 86.23 (82.06, 92.17) U/mL, 0.74 (0.35, 0.78) ng/mL and 2.42 (0.69, 5.60) ng/mL, respectively. The serum levels of BNP, TnI and IMA in the dead group were significantly higher than those in the survival group (all P < 0.05).  Conclusion  BNP, TnI and IMA can reflect the risk stratification and prognosis of acute pulmonary embolism, which is worthy of clinical reference.

     

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