Volume 20 Issue 2
Feb.  2022
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(2): 212-215
HUANG Xian-da, SHI Wei, GONG Quan, LI Shi-juan, ZHANG Li-juan, ZHOU Chun-yan, CHEN Xi, ZHUANG Li, WANG Cun-de. Clinical significance of the expression of algogenic substances and the change in immune function before and after control of cancer pain[J]. Chinese Journal of General Practice, 2022, 20(2): 212-215. doi: 10.16766/j.cnki.issn.1674-4152.002315
Citation: HUANG Xian-da, SHI Wei, GONG Quan, LI Shi-juan, ZHANG Li-juan, ZHOU Chun-yan, CHEN Xi, ZHUANG Li, WANG Cun-de. Clinical significance of the expression of algogenic substances and the change in immune function before and after control of cancer pain[J]. Chinese Journal of General Practice, 2022, 20(2): 212-215. doi: 10.16766/j.cnki.issn.1674-4152.002315
shu

Clinical significance of the expression of algogenic substances and the change in immune function before and after control of cancer pain

doi: 10.16766/j.cnki.issn.1674-4152.002315

  • Department of Palliative Medicine, Yunnan Tumor Hospital, the Third Affiliated Hospital of Kunming Medical University, Palliative Medicine Department of Yunnan Tumor Palliative Medicine Research Center, Kunming, Yunnan 650000, China

Funds:

 2016NS097

  • Received Date: 2021-05-11
    Available Online: 2022-03-04
    Abstract
  •   Objective  To explore the relationship between cancer pain and algogenic substances and immune function to screen out sensitive indicators for cancer-pain assessment and curative-effect monitoring, as well as to preliminary explore the role of algogenic substances in cancer pain.  Methods  A total of 60 patients with cancer pain diagnosed at the Yunnan Cancer Hospital from January 2016 to January 2019 were selected as the test group, and 30 healthy people and 30 patients with painless tumours were selected as the control group. Enzyme-linked immunosorbent assay was used to determine the levels of TNF-α, IL-6, β-endorphin, NGF, and LPA in plasma. Flow cytometry was used to detect the change in peripheral blood T lymphocyte subsets before and after cancer-pain control. The relationship of the expression of algogenic substances with the degree of cancer pain, outbreak pain, and distant metastasis was analysed statistically.  Results  The contents of TNF-α, IL-6, β-endorphin, NGF, and LPA in the experimental group were significantly higher than those in the control group. The levels of TNF-α, IL-6, β-endorphin, and NGF in serum after cancer-pain control were (87.77±11.60) ng/L, (33.33±6.43) ng/mL, (24.00±5.93) ng/mL, and (19.85±3.78) pg/mL, respectively. It was significantly lower than the level before cancer-pain control [(220.20±32.11) ng/L, (59.48±10.26) ng/mL, (38.62±8.01) ng/mL, (34.32±6.21) pg/mL], but no significant difference existed in LPA expression before and after cancer-pain control. The contents of TNF-α, IL-6, NGF, and LPA were related to the degree of cancer pain, outbreak pain, and distant metastasis. The expression level of β-endorphin was related to the degree of cancer pain and distant metastasis. The percentages of CD3+, CD4+, and CD4+/CD8+ after cancer pain control were significantly higher than those before cancer-pain control, but the percentage of CD8+ after cancer pain control was significantly lower than before cancer pain control, and the difference was statistically significant.  Conclusion  TNF-α, IL-6, β-endorphin, NGF, and LPA may play certain roles in cancer pain, which can be used to evaluate cancer pain and monitor therapeutic effect. Cancer pain can reduce the body's immune function.

     

    • FullText(HTML)
  • loading
    • References(20)
  • [1]
    吴艺舟, 林子晨, 孙杰. 基于肿瘤坏死因子TNF-α的癌症疼痛机制及临床治疗策略[J]. 医学理论与实践, 2018, 31(18): 2716-2719. https://www.cnki.com.cn/Article/CJFDTOTAL-YXLL201818012.htm
    [2]
    AL M S, FARHAT K, NEDJADI T, et al. Association of interleukin-6 and other cytokines with self-reported pain in prostate cancer patients receiving chemotherapy[J]. Pain Med, 2018, 19(5): 1058-1066. doi: 10.1093/pm/pnx145
    [3]
    CHONG D, SHAO L, YANG Y, et al. Correlations of cancer pain degree with levels of β-EP, CGRP and PGE2 and the effects of oxycontin on them[J]. J BUON, 2018, 23(5): 1552-1557. http://www.ncbi.nlm.nih.gov/pubmed/30570885
    [4]
    CHOI H Y, LEE C H. Can beta-endorphin be used as a biomarker for chronic low back pain? A meta-analysis of randomized controlled trials[J]. Pain Med, 2019, 20(1): 28-36. doi: 10.1093/pm/pny186
    [5]
    VELASCO M, O'SULLIVAN C, SHERIDAN G K. Lysophosphatidic acid receptors (LPARs): Potential targets for the treatment of neuropathic pain[J]. Neuropharmacology, 2017, 113(Pt B): 608-617. http://core.ac.uk/download/pdf/42557259.pdf
    [6]
    TREEDE R D, RIEF W, BARKE A, et al. Chronic pain as a symptom or a disease: The IASP classification of chronic pain for the international classification of diseases (ICD-11)[J]. Pain, 2019, 160(1): 19-27. doi: 10.1097/j.pain.0000000000001384
    [7]
    HAN L, JIANG J, XUE M, et al. Sonic hedgehog signaling pathway promotes pancreatic cancer pain via nerve growth factor[J]. Reg Anesth Pain Med, 2020, 45(2): 137-144. doi: 10.1136/rapm-2019-100991
    [8]
    李琪琪, 林健清. 小胶质细胞活化参与骨癌痛机制的研究进展[J]. 中国疼痛医学杂志, 2020, 26(9): 685-688. doi: 10.3969/j.issn.1006-9852.2020.09.009
    [9]
    ZHAO D, HAN D F, WANG S S, et al. Roles of tumor necrosis factor-α and interleukin-6 in regulating bone cancer pain via TRPA1 signal pathway and beneficial effects of inhibition of neuro-inflammation and TRPA1[J]. Mol Pain, 2019, 15: 1744806919857981. DOI: 10.1177/1744806919857981.
    [10]
    SCHEFF N N, YE Y, BHATTACHARYA A, et al. Tumor necrosis factor alpha secreted from oral squamous cell carcinoma contributes to cancer pain and associated inflammation[J]. Pain, 2017, 158(12): 2396-2409. doi: 10.1097/j.pain.0000000000001044
    [11]
    冯馨锐, 崔雨舒, 何志涛, 等. 肿瘤坏死因子-α的生物学功能研究进展[J]. 吉林医药学院学报, 2019, 40(1): 66-68. https://www.cnki.com.cn/Article/CJFDTOTAL-JLDS201901030.htm
    [12]
    BARKER P A, MANTYH P, ARENDT N L, et al. Nerve growth factor signaling and its contribution to pain[J]. J Pain Res, 2020, 13: 1223-1241. doi: 10.2147/JPR.S247472
    [13]
    OBREJA O, RUKWIED R, NAGLER L, et al. Nerve growth factor locally sensitizes nociceptors in human skin[J]. Pain, 2018, 159(3): 416-426. doi: 10.1097/j.pain.0000000000001108
    [14]
    DENK F, BENNETT D L, MCMAHON S B. Nerve growth factor and pain mechanisms[J]. Annu Rev Neurosci, 2017, 40: 307-325. doi: 10.1146/annurev-neuro-072116-031121
    [15]
    GUI Q, XU C, ZHANG L, et al. A new rat model of bone cancer pain produced by rat breast cancer cells implantation of the shaft of femur at the third trochanter level[J]. Cancer Biol Ther, 2013, 14(2): 193-199. doi: 10.4161/cbt.23291
    [16]
    SCARBOROUGH B M, SMITH C B. Optimal pain management for patients with cancer in the modern era[J]. CA Cancer J Clin, 2018, 68(3): 182-196. doi: 10.3322/caac.21453
    [17]
    崔爽, 国仁秀, 郑莹. 老年癌症患者疼痛评估工具的研究进展[J]. 中国医药导报, 2018, 15(32): 42-45. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY201832010.htm
    [18]
    卢正义, 胡壮文. 鞘内吗啡泵联合无线自控镇痛泵对于晚期癌痛患者细胞免疫功能和生存期的影响[J]. 中国药物与临床, 2019, 19(5): 750-752. https://www.cnki.com.cn/Article/CJFDTOTAL-YWLC201905029.htm
    [19]
    彭仁, 王永业. 镇痛疗法对肿瘤患者血T淋巴细胞亚群的影响[J]. 中国社区医师, 2018, 34(8): 93, 95. https://www.cnki.com.cn/Article/CJFDTOTAL-XCYS201808057.htm
    [20]
    孙峰, 鲍扬漪, 葛磊, 等. 癌痛对抑郁及免疫功能的影响[J]. 现代肿瘤医学, 2018, 26(8): 1263-1265. doi: 10.3969/j.issn.1672-4992.2018.08.029
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (321) PDF downloads(12) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return