The correlation between peritoneal fibrosis and the levels of SGLT1, TGF-β1, and VEGF in peritoneal dialysis patients and its application value

WANG Chao-chao; LIN Yong-qiang; CHEN Tian-tian; ZHOU Ying; CAI Xiao-qiao; LIN Sheng-fen

doi:10.16766/j.cnki.issn.1674-4152.002325

Volume 20 Issue 2

Feb. 2022

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Article Navigation > Chinese Journal of General Practice > 2022 > 20(2): 251-254

WANG Chao-chao, LIN Yong-qiang, CHEN Tian-tian, ZHOU Ying, CAI Xiao-qiao, LIN Sheng-fen. The correlation between peritoneal fibrosis and the levels of SGLT1, TGF-β1, and VEGF in peritoneal dialysis patients and its application value[J]. Chinese Journal of General Practice, 2022, 20(2): 251-254. doi: 10.16766/j.cnki.issn.1674-4152.002325

Citation:

WANG Chao-chao, LIN Yong-qiang, CHEN Tian-tian, ZHOU Ying, CAI Xiao-qiao, LIN Sheng-fen. The correlation between peritoneal fibrosis and the levels of SGLT1, TGF-β1, and VEGF in peritoneal dialysis patients and its application value[J]. Chinese Journal of General Practice, 2022, 20(2): 251-254. doi: 10.16766/j.cnki.issn.1674-4152.002325

Citation:

WANG Chao-chao, LIN Yong-qiang, CHEN Tian-tian, ZHOU Ying, CAI Xiao-qiao, LIN Sheng-fen. The correlation between peritoneal fibrosis and the levels of SGLT1, TGF-β1, and VEGF in peritoneal dialysis patients and its application value[J]. Chinese Journal of General Practice, 2022, 20(2): 251-254. doi: 10.16766/j.cnki.issn.1674-4152.002325

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The correlation between peritoneal fibrosis and the levels of SGLT1, TGF-β1, and VEGF in peritoneal dialysis patients and its application value

doi: 10.16766/j.cnki.issn.1674-4152.002325

1.
Nephrology Department, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, Zhejiang 325000, China

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LQ19H050002

Received Date: 2021-08-27
Available Online: 2022-03-04

Abstract

Abstract

Objective To investigate the correlation between peritoneal fibrosis and the levels of sodium-glucose transporter 1 (SGLT1), transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF) and its application value. Methods Twenty-five cases of patients with peritoneal fibrosis on maintenance hemodialysis were selected as study group, and 35 cases of peritoneal dialysis patients without peritoneal fibrosis were selected as the control group in Department of Nephrology, Wenzhou Integrated Traditional Chinese and Western Medicine Hospital from June 2012 to June 2021.The levels of SGLT1, TGF-β1 and VEGF of two groups were compared. The application value of SGLT1, TGF-β1, and VEGF of diagnosis of peritoneal fibrosis were analyzed by diagnosis of peritoneal fibrosis. Results The levels of SGLT [(128.85±22.58) pg/mL vs. (85.42±15.68) pg/mL], TGF-β1 [(432.32±54.18) pg/mL vs. (245.72±32.10) pg/mL], and VEGF [(903.25±61.45) ng/mL vs. (612.85±32.10) ng/mL] were statistically different between the two groups (all P < 0.05). The ROC curve analysis showed that the maximum area under the curve (AUC) were 0.865 (95% CI: 0.708-0.952), and the sensitivity and specificity were 85.02% and 82.14% when the three were diagnosed jointly. Conclusion Abnormally elevated levels of SGLT1, TGF-β1, and VEGF are closely related to the occurrence of peritoneal fibrosis. The levels of SGLT1, TGF-β1, and VEGF can effectively predict the occurrence of peritoneal fibrosis.
- Peritoneal dialysis,
- Peritoneal fibrosis,
- Sodium-glucose transporter 1,
- Transforming growth factor-β1,
- Vascular endothelial growth factor,
- Correlation

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The correlation between peritoneal fibrosis and the levels of SGLT1, TGF-β1, and VEGF in peritoneal dialysis patients and its application value

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