Volume 20 Issue 3
Mar.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(3): 379-383
WANG Bin, CAI Xue-fang, LIN Le-qing. Effect of recombinant human brain natriuretic peptide combined with levosimendan in patients with septic heart failure[J]. Chinese Journal of General Practice, 2022, 20(3): 379-383. doi: 10.16766/j.cnki.issn.1674-4152.002357
Citation: WANG Bin, CAI Xue-fang, LIN Le-qing. Effect of recombinant human brain natriuretic peptide combined with levosimendan in patients with septic heart failure[J]. Chinese Journal of General Practice, 2022, 20(3): 379-383. doi: 10.16766/j.cnki.issn.1674-4152.002357
shu

Effect of recombinant human brain natriuretic peptide combined with levosimendan in patients with septic heart failure

doi: 10.16766/j.cnki.issn.1674-4152.002357
  • 1.

    Department of Critical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310000, China

Funds:

 2020KY217

  • Received Date: 2021-03-18
    Available Online: 2022-08-13
    Abstract
  •   Objective  To explore and analyse the efficacy and safety of recombinant human brain natriuretic peptide (rh-BNP) combined with levosimendan in the treatment of septic heart failure, and analyse its effect on miR-132 and miR-31 levels in patients' peripheral blood.  Methods  A total of 117 patients with sepsis and heart failure who were admitted at the Affiliated Hospital of Hangzhou Normal University from March 2017 to June 2019 were selected. The random number table method was used to divide the observation group (61 cases) and the control group (56 cases). The control group was treated with levosimendan, and the observation group was treated with levosimendan combined with rh-BNP. The APACHE Ⅱ score, cardiac function indexes, myocardial enzyme spectrum, peripheral blood miR-132 and miR-31 and adverse reactions were compared between the two groups.  Results  After treatment, the APACHE Ⅱ score of the observation group[(14.62±1.74) points] was lower than that of the control group[(16.96±2.73) points, t=5.575, P < 0.05]. The LVEDD[(48.93±4.28) mm], LVESD[(39.42±4.16) mm] and LVFS[(22.31±1.75)%] of the observation group were lower than those of the control group[(52.18±3.95) mm, (42.28±3.74) mm, (24.97±1.89)%, respectively, t=4.257, 3.898, 7.905, all P < 0.05]. The serum LDH, CK and CK-MB levels in the observation group were lower than those in the control group (all P < 0.05). The relative expression of miR-31 in the peripheral blood of patients was positively correlated with LVEDD, LVESD, LDH, CK and CK-MB (all P < 0.05).  Conclusion  rh-BNP combined with levosimendan in the treatment of septic heart failure can effectively improve the clinical symptoms and cardiac function, and it can also improve the expression of miR-132 and miR-31 in the peripheral blood of patients.

     

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