Volume 20 Issue 3
Mar.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(3): 391-394
ZHU Guang-liang, SHEN Jun, LI Xiao-ming, CHEN Ben-xin. Application of meloxicam pretreatment combined with ultrasound-guided internal branch of superior laryngeal nerve block in perioperative period of radical thyroidectomy patients[J]. Chinese Journal of General Practice, 2022, 20(3): 391-394. doi: 10.16766/j.cnki.issn.1674-4152.002360
Citation: ZHU Guang-liang, SHEN Jun, LI Xiao-ming, CHEN Ben-xin. Application of meloxicam pretreatment combined with ultrasound-guided internal branch of superior laryngeal nerve block in perioperative period of radical thyroidectomy patients[J]. Chinese Journal of General Practice, 2022, 20(3): 391-394. doi: 10.16766/j.cnki.issn.1674-4152.002360
shu

Application of meloxicam pretreatment combined with ultrasound-guided internal branch of superior laryngeal nerve block in perioperative period of radical thyroidectomy patients

doi: 10.16766/j.cnki.issn.1674-4152.002360
  • 1.

    Department of Anesthesiology, Affiliated Hospital of West Anhui Health Vocational College, Lu'an, Anhui 237000, China

Funds:

 KJ2019A1259

  • Received Date: 2021-06-21
    Available Online: 2022-08-13
    Abstract
  •   Objective  To observe the effect of meloxicam pretreatment combined with ultrasound-guided internal branch of superior laryngeal nerve block in patients with radical thyroidectomy.  Methods  Seventy-six thyroid cancer patients admitted at the Affiliated Hospital of West Anhui Health Vocational College from December 2019 to February 2021 were selected and randomly divided into group M and group C, with 38 cases in each group. Group M was pretreated with meloxicam before operation, and group C was treated with placebo. Group M was given ultrasound-guided internal branch of superior laryngeal nerve block combined with general anaesthesia, whereas group C was given general anaesthesia. The hemodynamic indexes, postoperative VAS score, stress reaction, postoperative recovery and adverse reactions of the two groups were observed.  Results  The mean arterial pressure (MAP) and heart rate (HR) at T2, T3 and T4 in group M were lower than those in group C (all P < 0.05). The VAS score 2, 4, 12, 24 and 48 h after operation in group M were significantly lower than in group C (all P < 0.05). The levels of norepinephrine (NE), hs-CRP and IL-1β 24 h after operation in group M were significantly lower than those in group C (all P < 0.01). The levels of β Endorphins (β-EP) 24 h after operation in group M were significantly higher than those in group C (P < 0.01). The time of first intake, bedside activity time and length of hospital stay [(5.6±1.3) h, (16.2±4.7) h and (11.5±2.2) days] in group M were significantly lower than those in group C [(6.8±1.7) h, (18.9±5.3) h and (12.7±2.8) days], all P < 0.05. The incidence of coughing during emergence, antiemetic rescue and postoperative sore throat (7.9%, 13.2% and 13.2%) in group M were significantly lower than those in group C (39.5%, 42.1% and 39.5%, all P < 0.01). The incidence of nausea and vomiting (5.3%) in group M was significantly lower than that in group C (23.7%, P < 0.05). Conclusion Meloxicam pretreatment combined with ultrasound-guided internal branch of superior laryngeal nerve block effectively inhibits perioperative stress response, effectively relieves postoperative sore throat and promotes postoperative rehabilitation in patients with radical thyroidectomy.

     

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