Volume 20 Issue 3
Mar.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(3): 411-414
LI Wei-ling, JIN Xiao-ping, YU Dan, SHEN Yu-guang. Association between matrix metalloproteinase inhibitor-2 gene -418G/C polymorphisms and cerebral infarction with atrial fibrillation[J]. Chinese Journal of General Practice, 2022, 20(3): 411-414. doi: 10.16766/j.cnki.issn.1674-4152.002365
Citation: LI Wei-ling, JIN Xiao-ping, YU Dan, SHEN Yu-guang. Association between matrix metalloproteinase inhibitor-2 gene -418G/C polymorphisms and cerebral infarction with atrial fibrillation[J]. Chinese Journal of General Practice, 2022, 20(3): 411-414. doi: 10.16766/j.cnki.issn.1674-4152.002365
shu

Association between matrix metalloproteinase inhibitor-2 gene -418G/C polymorphisms and cerebral infarction with atrial fibrillation

doi: 10.16766/j.cnki.issn.1674-4152.002365

  • Department of Neurology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang 317000, China

Funds:

 LGF18H090019

 2020KY1035

  • Received Date: 2021-03-12
    Available Online: 2022-08-13
    Abstract
  •   Objective  Cerebral infarction caused by atrial fibrillation is a principal cause of high mortality in patients with ischaemic stroke. Considering the important role of matrix metalloproteinase inhibitor (TIMP) in the myocardial dimension process of atrial fibrillation, this study investigates the relationship between promoter region polymorphism (-418G/C) of TIMP-2 and cerebral infarction caused by atrial fibrillation.  Methods  Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect TIMP-2 gene promoter region -418G/C site polymorphism in 204 cases of cerebral infarction of atrial fibrillation (case group) and 248 cases of noncardiogenic cerebral infarction (control group) with first admission between January 2016 and June 2018. The general, genotype and all of the groups were compared.  Results  No significant differences in gender, age, tobacco and alcohol habits, systolic and diastolic blood pressure at admission, fasting glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol, fibrinogen and homocysteine were found between the case and control groups (all P>0.05). A total of 94 cases of the case group in GC+CC genotype accounted for 46.1%, and 90 cases of the control group in GC+CC genotype accounted for 36.3%; the difference between the two groups was statistically significant (P=0.043, 95% CI: 1.017-1.585). On the time, there were 115 cases of the case group in C allele, accounting for 28.2%, while 106 cases of the control group, accounting for 21.4%. The difference between the two groups was statistically significant (P=0.020, 95% CI: 1.049-1.658).  Conclusion  The TIMP-2 (-418gG/C) polymorphism may be associated with genetic susceptibility in cerebral infarction with atrial fibrillation.

     

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