Volume 20 Issue 3
Mar.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(3): 415-418
YU Hong-xia, CHEN Xiao-rong. Characteristics and influencing factors of anaemia in patients with type 2 diabetic nephropathy[J]. Chinese Journal of General Practice, 2022, 20(3): 415-418. doi: 10.16766/j.cnki.issn.1674-4152.002366
Citation: YU Hong-xia, CHEN Xiao-rong. Characteristics and influencing factors of anaemia in patients with type 2 diabetic nephropathy[J]. Chinese Journal of General Practice, 2022, 20(3): 415-418. doi: 10.16766/j.cnki.issn.1674-4152.002366
shu

Characteristics and influencing factors of anaemia in patients with type 2 diabetic nephropathy

doi: 10.16766/j.cnki.issn.1674-4152.002366
  • 1.

    Department of Science and Education, First People's Hospital of Fuyang District, Hangzhou, Hangzhou, Zhejiang 542899, China

Funds:

 2020ZH030

  • Received Date: 2021-08-04
    Available Online: 2022-08-13
    Abstract
  •   Objective  To analyse the characteristics and influencing factors of anaemia in patients with type 2 diabetic nephropathy.  Methods  A total of 185 patients with type 2 diabetic nephropathy treated in our hospital from January 2019 to April 2020 were selected as the observation group and divided into an anaemia group (n=52) and a non-anaemia group (n=133). A total of 105 patients with type 2 diabetes mellitus with normal urinary protein were selected as the control group. The characteristics and influencing factors of anaemia in patients with type 2 diabetic nephropathy were analysed.  Results  The incidence of anaemia in the observation group (28.11%) was significantly higher than that in the control group (3.81%, P < 0.01). In addition, 88.46% of the patients with anaemia had positive cell orthochromatic anaemia, 23.08% of the patients with anaemia had glomerular filtration rate (EGFR)>90 mL/(min·1.73 m2), 34.62% of the patients with anaemia had anaemia at the normal level of serum creatinine (SCR). The levels of SCR and cystatin C (Cys C) in the anaemia group were significantly higher than those in the non-anaemia group (all P < 0.01), whereas the levels of haemoglobin, EGFR, albumin (ALB) and prealbumin (PLB) in the anaemia group were significantly lower than those in the non-anaemia group (all P < 0.05). Elevated SCR, Cys-C, decreased EGFR, ALB and PLB were independent risk factors for anaemia in patients with type 2 diabetic nephropathy.  Conclusion  Patients with type 2 diabetic nephropathy have a high incidence of anaemia, mainly positive cell and positive pigment anaemia, and many patients have anaemia before the decrease of EGFR and when SCR is normal. Elevated SCR, Cys-C, decreased EGFR, ALB and PLB are independent risk factors for anaemia in patients with type 2 diabetic nephropathy.

     

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