Volume 20 Issue 4
Apr.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(4): 570-573
CAO Jie-qiong, PEI Xiao-yan, HU Hong-yan, JIN Guo-xi. Function and significance of serum ficolin-3 level in type 2 diabetes mellitus with peripheral neuropathy[J]. Chinese Journal of General Practice, 2022, 20(4): 570-573. doi: 10.16766/j.cnki.issn.1674-4152.002402
Citation: CAO Jie-qiong, PEI Xiao-yan, HU Hong-yan, JIN Guo-xi. Function and significance of serum ficolin-3 level in type 2 diabetes mellitus with peripheral neuropathy[J]. Chinese Journal of General Practice, 2022, 20(4): 570-573. doi: 10.16766/j.cnki.issn.1674-4152.002402
shu

Function and significance of serum ficolin-3 level in type 2 diabetes mellitus with peripheral neuropathy

doi: 10.16766/j.cnki.issn.1674-4152.002402

  • Department of Endocrinology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0353

  • Received Date: 2021-10-15
    Available Online: 2022-08-20
    Abstract
  •   Objective  To explore the relationship and significance of serum ficolin-3 level in type 2 diabetic peripheral neuropathy (DPN).  Methods  Eighty-eight T2DM patients who were hospitalised in the First Affiliated Hospital of Bengbu Medical College from October 2020 to May 2021 were selected and divided into the T2DM group (38 cases) and DPN group (50 cases) according to whether they were complicated with diabetic peripheral neuropathy. Another 30 healthy subjects were selected as the control group (NC group). Serum ficolin-3 levels were detected by enzyme-linked immunosorbent assay. Serum complement C3 concentration was determined by scattering turbidimetric method. The general biochemical indexes were detected by conventional methods.  Results  Ficolin-3 and C3 levels in the DPN group were lower than those in the T2DM and NC groups [ficolin-3: (19.19±3.37) ng/mL, (25.53±4.17) ng/mL, (24.57±4.19) ng/mL; C3: (0.95±0.39) g/L, (1.27±0.52) g/L, (1.24±0.28) g/L, all P < 0.05]. Pearson correlation analysis showed that ficolin-3 was positively correlated with C3 (r=0.223, P < 0.05) and negatively correlated with CRP and HOMA-IR (r=-0.254, -0.774, all P < 0.05). Binary logistic multifactor regression analysis showed that ficolin-3 levels (OR=0.686, 95% CI: 0.541-0.870), C3 levels (OR=0.205, 95% CI: 0.043-0.988) and the duration of diabetes (OR=1.158, 95% CI: 1.022-1.312) were independently correlated with DPN (P < 0.05).  Conclusion  Ficolin-3 may be involved in DPN by activating the complement pathway, aggravating inflammatory response and insulin resistance.

     

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