Volume 20 Issue 4
Apr.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(4): 574-577
DING Qun-li, YANG Li, WANG Hai, CHEN Zhong-bo, GU Ye. Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of isolated mediastinal and hilar lymphadenopathy[J]. Chinese Journal of General Practice, 2022, 20(4): 574-577. doi: 10.16766/j.cnki.issn.1674-4152.002403
Citation: DING Qun-li, YANG Li, WANG Hai, CHEN Zhong-bo, GU Ye. Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of isolated mediastinal and hilar lymphadenopathy[J]. Chinese Journal of General Practice, 2022, 20(4): 574-577. doi: 10.16766/j.cnki.issn.1674-4152.002403
shu

Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of isolated mediastinal and hilar lymphadenopathy

doi: 10.16766/j.cnki.issn.1674-4152.002403
  • 1.

    Department of Respiratory Medicine, the Affiliated Hospital of Medical School of Ningbo University, Ningbo, Zhejiang 315020, China

Funds:

 LBY22H180004

 2019A610228

  • Received Date: 2021-06-02
    Available Online: 2022-08-20
    Abstract
  •   Objective  To analyse the distribution of aetiology of isolated mediastinal and hilar lymphadenopathy (IMHL) and investigate the diagnostic value and safety of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA).  Methods  A total of 124 patients with thoracic CT examinations showing IMHL, which were examined at least once using EBUS-TBNA at the Shanghai Pulmonary Hospital, Tongji University Medical School and the Affiliated Hospital of Medical School of Ningbo University from August 2018 to January 2019, were retrospectively analysed, along with their pathology, cytology and microorganism results. Pathological study or follow-up visit was performed in the same period to make a final diagnosis, analyse the distribution of aetiology of IMHL and investigate the diagnostic value and safety of EBUS-TBNA.  Results  The study punctured 208 lymph nodes in total, with an average of 1.68 every case. Total 118 of 124 patients with IMHL obtained etiological diagnosis, with a diagnosis rate of 95.2%, including 43 cases of sarcoidosis (34.7%), 23 cases of lymph node tuberculosis (18.5%), 21 cases of neoplasms (16.9%), of which 11 cases were postoperative recurrence of pulmonary malignant tumors, 3 cases of lymphoma (2.4%), 28 cases of reactive hyperplasia of lymph nodes (22.7%), and 6 cases of unknown diagnosis. The diagnosis rate of neoplasms was 95.2%, that of tuberculosis was 82.6%, and that of sarcoidosis was 48.8%. The diagnostic accuracy of EBUS-TBNA was 72.6%, the specificity was 100.0%, and the negative predictive value was 50.0%.  Conclusion  The common causes of IMHL are sarcoidosis, tuberculosis and neoplasms. EBUS-TBNA is a safe, highly sensitive method that can be used to initially investigate patients with IMHL.

     

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