Volume 20 Issue 4
Apr.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(4): 665-668
CHEN Ke-long, CHEN Ling, SONG Cheng-cheng, LI Bin. Effect of Xiaoyao Powder and Banxia Houpu Decoction on cognitive function and event-related potential P300 in patients with liver depression and spleen deficiency depression[J]. Chinese Journal of General Practice, 2022, 20(4): 665-668. doi: 10.16766/j.cnki.issn.1674-4152.002425
Citation: CHEN Ke-long, CHEN Ling, SONG Cheng-cheng, LI Bin. Effect of Xiaoyao Powder and Banxia Houpu Decoction on cognitive function and event-related potential P300 in patients with liver depression and spleen deficiency depression[J]. Chinese Journal of General Practice, 2022, 20(4): 665-668. doi: 10.16766/j.cnki.issn.1674-4152.002425
shu

Effect of Xiaoyao Powder and Banxia Houpu Decoction on cognitive function and event-related potential P300 in patients with liver depression and spleen deficiency depression

doi: 10.16766/j.cnki.issn.1674-4152.002425

  • Department of Neurology, Wenzhou Hospital of Traditional Chinese Medicine, Wenzhou, Zhejiang 325000, China

Funds:

 2022ZH338

 2016ZA179

  • Received Date: 2021-12-14
    Available Online: 2022-08-20
    Abstract
  •   Objective  To observe the effects of Xiaoyao Powder and Banxia Houpu Decoction on cognitive function and event-related potential P300 in patients with liver depression and spleen deficiency depression.  Methods  Sixty patients with liver depression and spleen deficiency depression in Wenzhou Hospital of Traditional Chinese Medicine from April 2019 to October 2021 were randomly divided into study group and control group, with 30 patients in each group. The patients in the control group were treated with escitalopram tablets orally, whereas those in the study group were treated with Xiaoyao Powder and Banxia Houpu Decoction. Before and 8 weeks after treatment, the changes of depression and cognitive function were evaluated. The changes of event-related potential P300 and adverse drug reactions were observed.  Results  After 8 weeks of treatment, the Hamilton Depression Scale(HAMD) score of the study group [(12.67±1.62) points] was significantly lower than that of the control group [(15.37±1.42) points, t=6.838, P < 0.001]. The performances IQ (PIQ), verbal IQ (VIQ) and full intelligence quotient (FIQ) scores [(100.13±3.47) points, (104.57±3.04) points and (102.53±2.37) points, respectively] in the study group were significantly higher than those in the control group [(96.97±3.20) points, (102.37±2.85) points and (99.87±2.21) points, respectively, all P < 0.05]. The MQ scores [(77.77±3.32) points] in the study group were significantly higher than those in the control group [(73.27±3.04) points, t=5.468, P < 0.001]. The WCST score indexes of patients in the study group were significantly lower than those in the control group (all P < 0.05). The latency of event-related potential P300 in the study group was significantly lower than that in the control group, and the amplitude of event-related potential P300 was significantly higher than that in the control group (all P < 0.05). The incidence of adverse reactions in the study group (3.33%) was significantly lower than that in the control group (26.67%, χ2=4.706, P=0.030).  Conclusion  Xiaoyao Powder and Banxia Houpu Decoction can effectively reduce the severity of depressive symptoms in patients with liver depression and spleen deficiency depression, improve the recovery level of cognitive function and improve the neuroelectrophysiological status. They have high safety.

     

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