Volume 20 Issue 6
Jun.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(6): 990-992
WANG Hong, GUO An-ying. Effects of magnesium isoglycyrrhizinate on liver function, T lymphocyte subset and CMV-DNA in infants with anicteric cytomegalovirus hepatitis[J]. Chinese Journal of General Practice, 2022, 20(6): 990-992. doi: 10.16766/j.cnki.issn.1674-4152.002506
Citation: WANG Hong, GUO An-ying. Effects of magnesium isoglycyrrhizinate on liver function, T lymphocyte subset and CMV-DNA in infants with anicteric cytomegalovirus hepatitis[J]. Chinese Journal of General Practice, 2022, 20(6): 990-992. doi: 10.16766/j.cnki.issn.1674-4152.002506
shu

Effects of magnesium isoglycyrrhizinate on liver function, T lymphocyte subset and CMV-DNA in infants with anicteric cytomegalovirus hepatitis

doi: 10.16766/j.cnki.issn.1674-4152.002506
  • 1.

    Department of Pediatrics Gastroenterology, Ningbo Women and Children ' s Hospital, Ningbo, Zhejiang 315010, China

Funds:

 2021KY1059

  • Received Date: 2021-05-06
    Available Online: 2022-09-21
    Abstract
  •   Objective  To study the effect of magnesium isoglycyrrhizinate injection on liver function, T lymphocyte subsets and CMV-DNA in infants with anicteric cytomegalovirus (CMV) hepatitis.  Methods  A total of 60 infants with anicteric CMV hepatitis admitted to Ningbo Women and Children's Hospital from August 2017 to June 2020 were randomly divided into control group (n=30) and observation group (n=30).The control group was treated with reduced glutathione injection, whereas the observation group was treated with magnesium isoglycyrrhizinate injection for 2 weeks.The indexes of liver function, T lymphocyte subsets and CMV-DNA copies before and after treatment were compared between the two groups.The incidence of adverse reactions was also compared between the two groups.  Results  After treatment, the levels of ALT, AST and ALP in the observation group were significantly lower than those in the control group[(48.05±12.53) U/L vs.(72.34±20.60) U/L, (46.90±16.54) U/L vs.(81.35±22.36) U/L, (51.67±13.85) U/L vs.(80.21±16.39) U/L, t=5.518, 6.784, 7.285, all P < 0.001].The CD3+ and CD8+ levels were significantly lower in the observation group than those in the control group (all P < 0.001).The CD4+ and CD4+/CD8+ levels were significantly higher in the observation group than those in the control group (all P < 0.001).The copy number of CMV-DNA was significantly lower in the observation group than that in the control group (P < 0.001).The incidence of adverse reactions in the two groups were 20.00% and 13.33% respectively, with no significant difference (P=0.488).  Conclusion  Magnesium isoglycyrrhizinate is effective in the treatment of anicteric CMV hepatitis in infants, which can improve immune function and promote the recovery of liver function with less adverse reaction.

     

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