Volume 20 Issue 7
Jul.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(7): 1106-1108
ZHANG Fang, CHEN Guo-fan, WANG Ming-wei, REN Kai-han. Correlation between plasma homocysteine and blood pressure variability in patients with coronary heart disease complicated with hypertension[J]. Chinese Journal of General Practice, 2022, 20(7): 1106-1108. doi: 10.16766/j.cnki.issn.1674-4152.002534
Citation: ZHANG Fang, CHEN Guo-fan, WANG Ming-wei, REN Kai-han. Correlation between plasma homocysteine and blood pressure variability in patients with coronary heart disease complicated with hypertension[J]. Chinese Journal of General Practice, 2022, 20(7): 1106-1108. doi: 10.16766/j.cnki.issn.1674-4152.002534
shu

Correlation between plasma homocysteine and blood pressure variability in patients with coronary heart disease complicated with hypertension

doi: 10.16766/j.cnki.issn.1674-4152.002534

  • Department of Cardiology, Hangzhou Normal University, Hangzhou, Zhejiang 310015, China

Funds:

 2021KY890

  • Received Date: 2021-11-12
    Available Online: 2022-09-23
    Abstract
  •   Objective  To investigate the correlation between plasma homocysteine (Hcy) and blood pressure variability (BPV) in patients with coronary heart disease (CHD) complicated with hypertension.  Methods  A total of 146 cases of patients with CHD with high blood pressure from February 2019 to June 2020 in the hospital treatment were selected. In accordance with high Hcy, they were divided into observation group (78 cases, Hcy≥10 mmol/L) and control group (68 cases, Hcy levels < 10 mmol/L). The related clinical data of the two groups were compared. The correlation between plasma Hcy levels and BPV was analysed.  Results  Uric acid (UA), total cholesterol (TC), fasting blood glucose, Hcy, 24-h systolic blood pressure (24-h SBP), 24-h diastolic blood pressure (24-h DBP), 24-h systolic blood pressure variation (24-h SPV) and 24-h diastolic blood pressure variation (24-h DPV) in the observation group were significantly higher than in the control group (t=23.379, 4.233, 2.632, 111.075, 4.254, 9.452, 20.989 and 8.631, respectively; all P < 0.01). Pearson correlation analysis showed that UA, Hcy and TC were correlated with 24 h SBP, 24 h DBP and 24-h SPV, respectively, whilst DPV was positively correlated (r=0.349, 0.286, 0.413, 0.351, 0.507, 0.512, 0.518, 0.568, 0.326, 0.198, 0.348, 0.192, all P < 0.05). The results of multiple linear regression analysis showed that the influence of UA and TC on BPV index was adjusted Hcy level was positively correlated with 24 h SBP (β=0.023, P=0.029), 24-h DBP (β=0.028, P=0.034), 24-h SPV (β=0.156, P=0.005) and 24-h DPV (β=0.035, P=0.039).  Conclusion  A positive correlation existed between Hcy and BPV in patients with CHD complicated with hypertension. Hcy and BPV may interact with each other in promoting the occurrence and development of CHD. The changes of Hcy and BPV in these patients should be closely monitored clinically and the levels of Hcy and BPV should be actively controlled to improve the prevention and treatment effect of CHD.

     

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