Volume 20 Issue 7
Jul.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(7): 1135-1138
CHEN Jia, CHEN Xiang-yu, LUO Song. Effects of argatroban combined with butylphthalide soft capsule on NIHSS score and quality of life in patients with perforating cerebral infarction[J]. Chinese Journal of General Practice, 2022, 20(7): 1135-1138. doi: 10.16766/j.cnki.issn.1674-4152.002541
Citation: CHEN Jia, CHEN Xiang-yu, LUO Song. Effects of argatroban combined with butylphthalide soft capsule on NIHSS score and quality of life in patients with perforating cerebral infarction[J]. Chinese Journal of General Practice, 2022, 20(7): 1135-1138. doi: 10.16766/j.cnki.issn.1674-4152.002541
shu

Effects of argatroban combined with butylphthalide soft capsule on NIHSS score and quality of life in patients with perforating cerebral infarction

doi: 10.16766/j.cnki.issn.1674-4152.002541
  • 1.

    Department of Neurology, Tongling People's Hospital, Tongling, Anhui 244000, China

Funds:

 KJ2019A0364

  • Received Date: 2021-08-25
    Available Online: 2022-09-23
    Abstract
  •   Objective  To determine the clinical effect of argatroban combined with butylphthalide soft capsules in the treatment of perforating cerebral infarction.  Methods  Seventy-six patients with perforating cerebral infarction were enrolled and randomly divided into the study group (n=39) and control group (n=37). The patients in the control group were given clopidogrel bisulphate tablets on the basis of conventional therapy, and those in the study group were given argatroban and butylphthalide soft capsules. The National Institute of Health stroke scale (NIHSS) score, Barthel index (BI), incidence of progressive muscular dystrophy (PMD) and neurological recovery (mRS score) were compared. The World Health Organization Quality of Life-100 was used to evaluate the quality of life.  Results  At the 12th week, the NIHSS scores of the study group and control group were (4.1±1.7) points and (5.6±1.5) points, respectively. The study group had a significantly lower score (P < 0.05). The BI scores of the study group and control group were (76.9±16.3) points and (68.3±13.7) points, respectively. The study group had a significantly higher score (P < 0.05). The mRS scores of the study group and control group were (2.6±0.6) points and (2.9±0.8) points, respectively, with no statistical difference (P > 0.05). The results of the quality of life evaluation showed that the scores of physiological health, social relations and independent ability of the study group were significantly higher than those of the control group (all P < 0.05).  Conclusion  Argatroban combined with butylphthalide soft capsules has a good therapeutic effect and high application value on patients with perforating cerebral infarction.

     

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