Volume 20 Issue 8
Aug.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(8): 1277-1282
LIN Yong-juan, JIANG Cheng, HUANG Ming-min, LI Ling-ling. Association of high residual cholesterol levels and Lp-PLA2 expression in elderly patients with acute ischemic stroke[J]. Chinese Journal of General Practice, 2022, 20(8): 1277-1282. doi: 10.16766/j.cnki.issn.1674-4152.002576
Citation: LIN Yong-juan, JIANG Cheng, HUANG Ming-min, LI Ling-ling. Association of high residual cholesterol levels and Lp-PLA2 expression in elderly patients with acute ischemic stroke[J]. Chinese Journal of General Practice, 2022, 20(8): 1277-1282. doi: 10.16766/j.cnki.issn.1674-4152.002576
shu

Association of high residual cholesterol levels and Lp-PLA2 expression in elderly patients with acute ischemic stroke

doi: 10.16766/j.cnki.issn.1674-4152.002576

  • Department of Geriatric, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China

Funds:

 81400965

 BJ18006

  • Received Date: 2021-12-20
    Available Online: 2022-09-26
    Abstract
  •   Objective  To investigate the correlation between residual cholesterol (RC) and lipoprotein-related phospholipase A2 (Lp-PLA2) and evaluated their predictive value in elderly patients with acute ischemic stroke (AIS) and high RC.  Methods  A total of 162 elderly AIS patients with high RC (observation group) admitted in Nanjing Drum Tower Hospital from Jan. 2019 to Mar. 2021 were included in the study, and 165 normal RC-AIS patients during the same period were selected as the control group. The levels of blood lipid parameters and Lp-PLA2 in the two groups were compared, and the correlation between RC and Lp-PLA2 were analysed by the Pearson method. ROC analysis was used to evaluate the predictive value of RC and Lp-PLA2 in neurological impairment.  Results  The levels of Lp-PLA2 and National Institute of Health stroke scale (NIHSS) score after treatment in the observation group were significantly higher than those in the control group (Z=4.361, 2.182, all P < 0.05). Logistic regression analysis showed that Lp-PLA2 (95% CI: 1.000-1.007, P=0.045) and NIHSS score after treatment (95% CI: 1.026-1.369, P=0.021) were independent factors of RC levels in patients with AIS. RC, Lp-PLA2 and NIHSS score after treatment in patients with AIS were positively correlated with each other (r=0.683, 0.635, 0.640, all P < 0.001). The area under the ROC curve for serum RC>0.845 mmol/L and Lp-PLA2>242 ng/mL in predicting the severity of AIS were 0.835 and 0.854, respectively. When combined with two indicators, the AUC was 0.897.  Conclusion  Lp-PLA2 levels were significantly increased in patients with high RC-AIS. A positive correlation was found between the levels of RC and Lp-PLA2. High levels of RC or Lp-PLA2 have a good value in predicting the degree of neurological impairment and the prognosis after treatment of patients with AIS.

     

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    • References(21)
  • [1]
    SMITH J W, BARLAS R S, MAMAS M A, et al. Association between serum secretory phospholipase A2 and risk of ischaemic stroke[J]. Eur J Neurol, 2021, 28(11): 3650-3655. doi: 10.1111/ene.15004
    [2]
    IZUMIDA T, NAKAMURA Y, HINO Y, et al. Combined effect of small dense low-density lipoprotein cholesterol (sdLDL-C) and remnant-like particle cholesterol (RLP-C) on low-grade inflammation[J]. J Atheroscler Thromb, 2020, 27(4): 319-330. doi: 10.5551/jat.49528
    [3]
    郝泽林, 吴建跃, 滕振飞, 等. 急性脑梗死患者血清学指标与神经功能缺损和脑梗死体积及颈动脉斑块性质的相关性研究[J]. 中华全科医学, 2020, 18(11): 1803-1806. doi: 10.16766/j.cnki.issn.1674-4152.001623

    HAO Z L, WU J Y, TENG Z F, et al. Correlation of hs-CRP, MMP-9 and Lp-PLA2 with neurological deficit, cerebral infarction volume and carotid plaque properties in patients with acute cerebral infarction[J]. Chinese Journal of General Practice, 2020, 18(11): 1803-1806. doi: 10.16766/j.cnki.issn.1674-4152.001623
    [4]
    高腾龙, 钱文茹, 赵春生, 等. 残余胆固醇与急性冠脉综合征发病相关性的研究[J]. 河北医学, 2021, 27(2): 276-278. doi: 10.3969/j.issn.1006-6233.2021.02.021

    GAO T L, QIAN W R, ZHAO C S, et al. A Research on the Relevance of Residual Cholesterol to Acute Coronary Syndrome[J]. Hebei Medicine, 2021, 27(2): 276-278. doi: 10.3969/j.issn.1006-6233.2021.02.021
    [5]
    杜晓辉. 血清脂蛋白a和游离脂肪酸水平与冠心病患者颈动脉粥样硬化的相关性[J]. 医药论坛杂志, 2021, 42(19): 120-122. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYX202119029.htm

    DU X H. Correlation between serum lipoprotein A and free fatty acid levels and carotid atherosclerosis in patients with coronary heart disease[J]. Journal of Medical Forum, 2021, 42(19): 120-122. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYX202119029.htm
    [6]
    SUCATO V, COPPOLA G, TESTA G, et al. Evaluation of remnant cholesterol levels and Monocyte-to-HDL-cholesterol ratio in South Asian patients with acute coronary syndrome[J]. Nutr Metab Cardiovasc Dis, 2021, 31(7): 2144-2150. doi: 10.1016/j.numecd.2021.04.007
    [7]
    VARBO A, NORDESTGAARD B G. Remnant cholesterol and risk of ischemic stroke in 112, 512 individuals from the general population[J]. Ann Neurol, 2019, 85(4): 550-559. doi: 10.1002/ana.25432
    [8]
    WANG Y, HU S Y, REN L T, et al. Lp-PLA2 as a risk factor of early neurological deterioration in acute ischemic stroke with TOAST type of large arterial atherosclerosis[J]. Neurol Res, 2019, 41(1): 1-8. doi: 10.1080/01616412.2018.1493850
    [9]
    LIANG T, WANG S C, ZHANG D T, et al. Evaluation of lipoprotein-associated phospholipase A2, serum amyloid A, and fibrinogen as diagnostic biomarkers for patients with acute cerebral infarction[J]. J Clin Lab Anal, 2020, 34(3): e23084. DOI: 10.1002/jcla.23084.
    [10]
    CASTANER O, PINTO X, SUBIRANA I, et al. Remnant cholesterol, not LDL cholesterol, is associated with incident cardiovascular disease[J]. J Am Coll Cardiol, 2020, 76(23): 2712-2724. doi: 10.1016/j.jacc.2020.10.008
    [11]
    HERPICH F, RINCON F. Management of acute ischemic stroke[J]. Crit Care Med, 2020, 48(11): 1654-1663. doi: 10.1097/CCM.0000000000004597
    [12]
    FUJIHARA Y, NAKAMURA T, HORIKOSHI T, et al. Remnant lipoproteins are residual risk factor for future cardiovascular events in patients with stable coronary artery disease and on-statin low-density lipoprotein cholesterol levels < 70 mg/dL[J]. Circ J, 2019, 83(6): 1302-1308. doi: 10.1253/circj.CJ-19-0047
    [13]
    BIAN L, MAO L G, SUN Y, et al. Serum lipoprotein-associated phospholipase A2 as a promising prognostic biomarker in association with 90-day outcome of acute intracerebral hemorrhage[J]. Clin Chim Acta, 2019, 495: 429-435. doi: 10.1016/j.cca.2019.05.017
    [14]
    BERNELOT MOENS S J, VERWEIJ S L, SCHNITZLER J G, et al. Remnant cholesterol elicits arterial wall inflammation and a multilevel cellular immune response in humans[J]. Arterioscler Thromb Vasc Biol, 2017, 37(5): 969-975. doi: 10.1161/ATVBAHA.116.308834
    [15]
    来佳成, 韩永生. 脂蛋白相关磷脂酶A2与颈动脉粥样硬化病变程度的相关性研究[J]. 中华全科医学, 2021, 19(10): 1626-1628, 1705. doi: 10.16766/j.cnki.issn.1674-4152.002127

    LAI J C, HAN Y S. Relationship between lipoprotein-associated phospholipase A2 with degree of carotid atherosclerosis[J]. Chinese Journal of General Practice, 2021, 19(10): 1626-1628, 1705. doi: 10.16766/j.cnki.issn.1674-4152.002127
    [16]
    刘莉, 吴钢, 吴庆, 等. 外周血脂蛋白相关磷脂酶水平与糖尿病患者冠状动脉硬化斑块的相关性研究[J]. 中华全科医学, 2020, 18(1): 68-70, 118. doi: 10.16766/j.cnki.issn.1674-4152.001170

    LIU L WU G WU Q, et al. Study on the relationship between the level of Lp-PLA2 in peripheral blood and coronary atherosclerotic plaque in diabetic patients[J]. Chinese Journal of General Practice, 2020, 18(1): 68-70, 118. doi: 10.16766/j.cnki.issn.1674-4152.001170
    [17]
    ELSHAZLY M B, MANI P, NISSEN S, et al. Remnant cholesterol, coronary atheroma progression and clinical events in statin-treated patients with coronary artery disease[J]. Eur J Prev Cardiol, 2020, 27(10): 1091-1100. doi: 10.1177/2047487319887578
    [18]
    TUREK-JAKUBOWSKA A, DEBSKI J, JAKUBOWSKI M, et al. New candidates for biomarkers and drug targets of ischemic stroke-a first dynamic LC-MS human serum proteomic study[J]. J Clin Med, 2022, 11(2): 339. doi: 10.3390/jcm11020339
    [19]
    MELITA H, MANOLIS A A, MANOLIS T A, et al. Lipoprotein(a) and cardiovascular disease: A missing link for premature atherosclerotic heart disease and/or residual risk[J]. J Cardiovasc Pharmacol, 2022, 79(1): e18-e35.
    [20]
    AMBROSY A P, YANG J, SUNG S H, et al. Triglyceride levels and residual risk of atherosclerotic cardiovascular disease events and death in adults receiving statin therapy for primary or secondary prevention: Insights from the KP REACH study[J]. J Am Heart Assoc, 2021, 10(20): e020377. DOI: 10.1161/JAHA.120.020377.
    [21]
    WOO J S, HONG S J, CHA D H, et al. Comparison of the efficacy and safety of atorvastatin 40 mg/omega-3 fatty acids 4 g fixed-dose combination and atorvastatin 40 mg monotherapy in hypertriglyceridemic patients who poorly respond to atorvastatin 40 mg monotherapy: An 8-week, multicenter, randomized, double-blind phase Ⅲ study[J]. Clin Ther, 2021, 43(8): 1419-1430.
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